Mederake Moritz, Hofmann Ulf Krister, Fink Bernd
Department of Orthopaedic Surgery, University Hospital Tübingen, Hoppe Seyler-Str. 3, 72076 Tübingen, Germany.
Department of Arthroplasty and Revision Arthroplasty, Orthopaedic Clinic Markgröningen GmbH, Kurt-Lindemann-Weg 10, 71706 Markgröningen, Germany.
Antibiotics (Basel). 2021 Sep 4;10(9):1073. doi: 10.3390/antibiotics10091073.
The choice of spacer in the interim phase of two-stage revision hip arthroplasty is crucial. Conventional concepts like a Girdlestone situation, handformed or preformed bone cement spacers show complications like soft-tissue contractions, abrasion of bone cement particles, dislocation, breakage and a low level of mobility in the interim phase. To address these disadvantages, the senior author developed a new technique for custom-made spacers in septic two-stage revision of total hip arthroplasties using prosthetic implants with individualized antibiotic mixture in the cement applying a mechanical inferior cementation method. The aim of this study was to evaluate the results of these spacers with respect to their non-inferiority in terms of reinfection and survival-rate of the new implant and to describe the complications associated with this procedure. Our collective consisted of 130 patients with a median follow-up of nearly five years. With a reinfect-free rate of 92% and a spacer-related complication rate of 10% (8% articular dislocation, 1% periprosthetic joint fracture, 1% breakage), this procedure seems to be safe and superior regarding complications compared to conventional concepts. Further studies are necessary to show the clinical benefit of this procedure.
两阶段翻修髋关节置换术过渡阶段间隔物的选择至关重要。诸如吉尔德斯通(Girdlestone)情况、手工制作或预制骨水泥间隔物等传统概念在过渡阶段存在软组织挛缩、骨水泥颗粒磨损、脱位、断裂以及活动度低等并发症。为解决这些缺点,资深作者开发了一种新技术,用于在全髋关节置换术的感染性两阶段翻修中定制间隔物,在骨水泥中使用含个体化抗生素混合物的假体植入物,并采用机械性低位骨水泥固定方法。本研究的目的是评估这些间隔物在再感染和新植入物生存率方面的非劣效性结果,并描述与该手术相关的并发症。我们的研究对象包括130例患者,中位随访时间近五年。再感染率为92%,间隔物相关并发症发生率为10%(关节脱位8%、假体周围骨折1%、断裂1%),与传统概念相比,该手术在并发症方面似乎更安全且更具优势。需要进一步研究以证明该手术的临床益处。