Wang Xiuxiu, Liu Xiaoyu, Jia Zhenzhen, Zhang Yilun, Wang Shuo, Zhang Hongyan
Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, China.
School of Medicine, Nankai University, Tianjin 300457, China.
Foods. 2021 Sep 19;10(9):2223. doi: 10.3390/foods10092223.
The occurrence and development of breast cancer are closely related to dietary factors, especially dietary patterns. This study was to investigate the effects of dietary patterns on the process of tumor metastasis by circulating tumor cell (CTC) capture strategy and monitoring changes of CTC numbers in breast tumor mice model. Meanwhile, the effects of different dietary patterns on the development of lung metastases of breast cancer and the volume and weight of carcinoma in situ were investigated. In this study, the increase in the number of CTCs was significantly promoted by dietary patterns such as high-salt diet, high-sugar diet, and high-fat diet, while it was delayed by ketogenic diet, low-fat diet, low-protein diet, diet restriction, and Mediterranean diet. These results indicated that the capture and detection of CTCs provides a convenient method for real-time cancer metastasis monitoring, and through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, it can expand a new horizon in future cancer treatments.
乳腺癌的发生与发展与饮食因素密切相关，尤其是饮食模式。本研究旨在通过循环肿瘤细胞（CTC）捕获策略，研究饮食模式对肿瘤转移过程的影响，并监测乳腺肿瘤小鼠模型中CTC数量的变化。同时，研究了不同饮食模式对乳腺癌肺转移发生以及原位癌体积和重量的影响。在本研究中，高盐饮食、高糖饮食和高脂饮食等饮食模式显著促进了CTC数量的增加，而生酮饮食、低脂饮食、低蛋白饮食、饮食限制和地中海饮食则延缓了这一增加。这些结果表明，CTC的捕获和检测为实时癌症转移监测提供了一种便捷的方法，通过深入研究不同饮食模式对肿瘤生长和转移的影响，可为未来癌症治疗开辟新的视野。
