比较低蛋白和高碳水化合物饮食以及热量限制对小鼠大脑衰老的影响。
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.
机构信息
Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Centre for Education and Research on Ageing, Concord, NSW 2139, Australia.
Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
出版信息
Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.
Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compared hippocampus biology and memory in mice subjected to 20% CR or provided ad libitum access to one of three LPHC diets or to a control diet. Patterns of RNA expression in the hippocampus of 15-month-old mice were similar between mice fed CR and LPHC diets when we looked at genes associated with longevity, cytokines, and dendrite morphogenesis. Nutrient-sensing proteins, including SIRT1, mTOR, and PGC1α, were also influenced by diet; however, the effects varied by sex. CR and LPHC diets were associated with increased dendritic spines in dentate gyrus neurons. Mice fed CR and LPHC diets had modest improvements in the Barnes maze and novel object recognition. LPHC diets recapitulate some of the benefits of CR on brain aging.
热量限制（CR）可延长小鼠寿命并改善大脑健康。随意进食低蛋白、高碳水化合物（LPHC）饮食也能延长寿命，但尚不清楚它们是否有益于大脑健康。我们比较了接受 20%CR 或随意进食三种 LPHC 饮食之一或对照饮食的小鼠的海马体生物学和记忆。当我们观察与长寿、细胞因子和树突形态发生相关的基因时，15 个月大的小鼠的海马体中的 RNA 表达模式在接受 CR 和 LPHC 饮食的小鼠之间相似。包括 SIRT1、mTOR 和 PGC1α 在内的营养感应蛋白也受饮食影响；然而，其影响因性别而异。CR 和 LPHC 饮食与齿状回神经元中的树突棘增加有关。接受 CR 和 LPHC 饮食的小鼠在 Barnes 迷宫和新物体识别测试中均有适度改善。LPHC 饮食再现了 CR 对大脑衰老的一些益处。
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