Department of Oral and Maxillofacial Surgery, Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia.
University Medical Center Groningen, Department of Oral and Maxillofacial Surgery, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Int J Environ Res Public Health. 2021 Sep 10;18(18):9560. doi: 10.3390/ijerph18189560.
A particular role for (Pg) and (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies.
（Pg）和（Aa）在牙周炎和类风湿关节炎（RA）中具有特定作用，因为这些细菌可能引发类风湿因子（RF）和抗瓜氨酸蛋白自身抗体（ACPA）的形成。我们评估了 RA 患者和非 RA 对照组血清中针对 Pg 和 Aa 的抗体是否反映了 Pg 和 Aa 的龈下存在，并评估了这些抗体与牙周炎炎症严重程度和 RA 特异性血清自身抗体的关系。在 70 名印度尼西亚 RA 患者和 70 名非 RA 对照组中，通过细菌 16S rRNA 基因测序评估 Pg 和 Aa 的龈下存在，并测定针对 Pg 和 Aa 的血清 IgG 水平。同时，测量 ACPA（ACPA：IgG，IgA）和 RF（RF：IgM，IgA）的血清水平。牙周炎炎症程度通过牙周炎炎症表面面积评估。在 RA 患者和对照组中，龈下 Pg 和 Aa 的存在相似，抗 Pg 和抗 Aa 抗体水平与 Pg 和 Aa 的龈下存在相关，抗 Pg 与 ACPA 或 RF 水平无关。龈下 Pg 和 Aa 与 RA 无关。未检测到针对 Pg 和 Aa 的抗体与 RA 特异性自身抗体之间存在显著相关性。
