Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Int J Environ Res Public Health. 2021 Sep 10;18(18):9567. doi: 10.3390/ijerph18189567.
Ketamine use has become of increasing concern because it has spread in many parts of the world during the past few years. Substance users usually have depression and a lower quality of life (QoL). The aim of this study was to explore depression and QoL in ketamine users, and to further examine the role of gender in relation to differences in depression and QoL in ketamine users. This study recruited 204 current ketamine users, 102 abstinent ketamine users and 102 healthy controls. The demographic data, severity of depression and QoL were recorded. Analysis of Variance (ANOVA) was employed to compare the associations of ketamine use status with depression and QoL. Gender differences were examined by moderator analysis. The current ketamine users with and without ketamine use disorder, in addition to the abstinent ketamine users with ketamine use disorder, have more severe depression and a lower QoL than healthy controls. There were significant gender differences in depression and QoL in abstinent ketamine users with ketamine use disorder. Ketamine users have more severe depression and a lower QoL. In particular, depression and a lower QoL are still prominent in abstinent ketamine users. The gender differences in depression and QoL are significant in abstinent ketamine users.
氯胺酮的使用越来越受到关注，因为在过去几年中，它已经在世界许多地方传播。物质使用者通常患有抑郁症和生活质量（QoL）较低。本研究旨在探讨氯胺酮使用者的抑郁和 QoL，并进一步研究性别在与氯胺酮使用者的抑郁和 QoL 差异相关方面的作用。本研究招募了 204 名现用氯胺酮使用者、102 名戒断氯胺酮使用者和 102 名健康对照者。记录了人口统计学数据、抑郁严重程度和 QoL。方差分析（ANOVA）用于比较氯胺酮使用状况与抑郁和 QoL 的关联。通过调节分析检查了性别差异。有和没有氯胺酮使用障碍的当前氯胺酮使用者，以及有氯胺酮使用障碍的戒断氯胺酮使用者，与健康对照组相比，抑郁程度更严重，生活质量更低。有氯胺酮使用障碍的戒断氯胺酮使用者的抑郁和 QoL 存在显著的性别差异。氯胺酮使用者的抑郁程度更严重，生活质量更低。特别是，在戒断氯胺酮使用者中，抑郁和较低的生活质量仍然很突出。在戒断氯胺酮使用者中，抑郁和 QoL 的性别差异显著。
