Skibinska Maria, Kapelski Pawel, Dmitrzak-Weglarz Monika, Lepczynska Natalia, Pawlak Joanna, Twarowska-Hauser Joanna, Szczepankiewicz Aleksandra, Rajewska-Rager Aleksandra
Department of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland.
Department of Child and Adolescent Psychiatry, Karol Jonscher Clinical Hospital, Poznan University of Medical Sciences, Szpitalna 27/33 St., 60-572 Poznan, Poland.
J Clin Med. 2021 Sep 8;10(18):4064. doi: 10.3390/jcm10184064.
Bipolar disorder (BD) is a chronic mental disorder that affects more than 1% of the population worldwide. Over 65% of patients experience early onset of the disease. Most cases of juvenile bipolar disorder begin with a depressed mood episode, and up to 50% of youth initially diagnosed with major depression go onto developing a BD. Our study aimed to find biomarkers of diagnosis conversion in young patients with mood disorders. We performed a two-year follow-up study on 79 adolescent patients diagnosed with MDD or BD, with a detailed clinical assessment at five visits. We monitored diagnosis change from MDD to BD. The control group consisted of 31 healthy youths. According to the neurodevelopmental and neuroimmunological hypotheses of mood disorders, we analyzed serum levels of brain-derived neurotrophic factor (BDNF), proBDNF, epidermal growth factor (EGF), migration inhibitory factor (MIF), stem cell factor (SCF), and correlations with clinical factors. We detected a significant disease-dependent increase in EGF level in MDD and BP patients at baseline exacerbation of depressive or hypomanic/manic episodes as well as in euthymic state compared to healthy controls. No potential biological predictors of disease conversion were found. Replication studies on a larger cohort of patients are needed.
双相情感障碍（BD）是一种慢性精神障碍，全球超过1%的人口受其影响。超过65%的患者疾病发病较早。大多数青少年双相情感障碍病例始于抑郁发作，最初被诊断为重度抑郁症的青少年中，高达50%最终会发展为双相情感障碍。我们的研究旨在寻找情绪障碍年轻患者诊断转换的生物标志物。我们对79名被诊断为重度抑郁症（MDD）或双相情感障碍的青少年患者进行了为期两年的随访研究，在五次就诊时进行了详细的临床评估。我们监测了从重度抑郁症到双相情感障碍的诊断变化。对照组由31名健康青少年组成。根据情绪障碍的神经发育和神经免疫假说，我们分析了血清中脑源性神经营养因子（BDNF）、前体脑源性神经营养因子（proBDNF）、表皮生长因子（EGF）、迁移抑制因子（MIF）、干细胞因子（SCF）的水平以及与临床因素的相关性。我们检测到，与健康对照组相比，在抑郁或轻躁狂/躁狂发作的基线加重期以及心境正常状态下，重度抑郁症和双相情感障碍患者的表皮生长因子水平存在显著的疾病依赖性升高。未发现疾病转换的潜在生物学预测指标。需要在更大规模患者队列中进行重复研究。
