Semel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center (MC), Los Angeles, CA.
Am J Geriatr Psychiatry. 2023 Jan;31(1):22-32. doi: 10.1016/j.jagp.2022.08.004. Epub 2022 Aug 27.
Underlying inflammation is associated with an increased risk of depression in older adults. In this study, we examined the role of inflammatory biomarkers in antidepressant response in depressed older adults undergoing adjunct Tai Chi Chih (TCC) or Health education interventions.
Older adults aged 60 years and above with a diagnosis of major depression were randomized to 12 weeks of TCC versus Health and Wellness Education (HEW) as an adjunct therapy to their stable antidepressant treatment regimen. A panel of 19 cytokine/chemokines was measured at baseline and 12 weeks. Five factors were derived using factor analysis. General linear models were estimated to examine the change in factor scores and the association of these changes on depression remission rates, controlling for age, sex, and body mass index.
Of the 170 randomized participants (TCC: n = 85 and HEW: n = 85), 55 TCC and 58 HEW completed the 3-month assessment. The groups did not differ at baseline in any measure. At follow-up, neither the changes in cytokine/chemokines scores nor the depression remission rate differed significantly between TCC and HEW. However, remitters and non-remitters differed significantly in changes in a factor composed of growth-regulated oncogene protein-alpha (GRO-alpha), epidermal growth factor (EGF), and soluble CD40 ligand (sCD40L). GRO-alpha and EGF levels (in both groups) were significantly increased in remitters compared to non-remitters.
Changes in certain cytokines/chemokines may accompany improvement in depressive symptoms in older adults. Future studies will need to explore the role of these molecules in remission of late-life depression.
潜在炎症与老年人抑郁风险增加有关。在这项研究中，我们研究了炎症生物标志物在接受辅助太极拳气功（TCC）或健康教育干预的老年抑郁症患者抗抑郁反应中的作用。
年龄在 60 岁及以上、被诊断患有重度抑郁症的成年人被随机分为 TCC 组和健康与健康促进教育（HEW）组，作为其稳定抗抑郁治疗方案的辅助治疗。在基线和 12 周时测量了一组 19 种细胞因子/趋化因子。使用因子分析得出了五个因子。估计了一般线性模型，以检查因子评分的变化以及这些变化与抑郁缓解率的关联，同时控制年龄、性别和体重指数。
在 170 名随机参与者（TCC：n=85 和 HEW：n=85）中，有 55 名 TCC 和 58 名 HEW 完成了 3 个月的评估。两组在任何测量指标上均无差异。在随访时，TCC 和 HEW 之间细胞因子/趋化因子评分的变化或抑郁缓解率均无显著差异。然而，缓解者和非缓解者在由生长调节致癌基因蛋白-α（GRO-α）、表皮生长因子（EGF）和可溶性 CD40 配体（sCD40L）组成的因子的变化方面存在显著差异。与非缓解者相比，GRO-α 和 EGF 水平（在两组中）在缓解者中显著增加。
某些细胞因子/趋化因子的变化可能伴随着老年抑郁症患者抑郁症状的改善。未来的研究需要探索这些分子在老年抑郁症缓解中的作用。
