Aguirre Garbine, Taboada Pablo, Billon Laurent
Institut des Sciences Analytiques & de PhysicoChimie pour l'Environnement & les Matériaux, Universite de Pau et des Pays de l'Adour, E2S UPPA, CNRS, UMR5254, 64000 Pau, France.
Bio-Inspired Materials Group, Functionalities & Self-Assembly, Universite de Pau et des Pays de l'Adour, E2S UPPA, Hélioparc, 2 Avenue Angot, 64000 Pau, France.
Pharmaceutics. 2021 Sep 8;13(9):1422. doi: 10.3390/pharmaceutics13091422.
Nowadays, the design of innovative delivery systems is driving new product developments in the field of skincare. In this regard, serving as potential candidates for on-demand drug delivery and fulfilling advanced mechanical and optical properties together with surface protection, spontaneously self-assembled microgel films can be proposed as ideal smart skincare systems. Currently, the high encapsulation of more than one drug simultaneously in a film is a very challenging task. Herein, different ratios (1:1, 3:1, 9:1) of different mixtures of hydrophilic/hydrophobic UVA/UVB-absorbers working together in synergy and used for skin protection were encapsulated efficiently into spontaneously self-assembled microgel films. In addition, in vitro release profiles show a controlled release of the different active molecules regulated by the pH and temperature of the medium. The analysis of the release mechanisms by the Peppas-Sahlin model indicated a superposition of diffusion-controlled and swelling-controlled releases. Finally, the distribution of active molecule mixtures into the film was studied by confocal Raman microscopy imaging corroborating the release profiles obtained.
如今，创新给药系统的设计推动着护肤品领域的新产品开发。在这方面，自发自组装微凝胶薄膜作为按需给药的潜在候选者，兼具先进的机械和光学性能以及表面保护功能，可被视为理想的智能护肤系统。目前，在薄膜中同时高效封装多种药物是一项极具挑战性的任务。在此，具有协同作用且用于皮肤保护的亲水性/疏水性UVA/UVB吸收剂不同混合物的不同比例（1:1、3:1、9:1）被有效地封装到自发自组装微凝胶薄膜中。此外，体外释放曲线表明，不同活性分子的释放受介质的pH值和温度控制。通过Peppas-Sahlin模型对释放机制的分析表明，其为扩散控制释放和溶胀控制释放的叠加。最后，通过共聚焦拉曼显微镜成像研究了活性分子混合物在薄膜中的分布情况，证实了所获得的释放曲线。
