Tokunaga Y, Konishi Y, Nakamoto K, Ohara H, Terai T, Yamauchi Y, Nagano Y
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 1):1070-3.
Two cases of postoperative brain metastasis of breast cancer were evaluated after chemotherapy using ACNU. Case 1: A 47-year-old female, who had undergone right standard radical mastectomy in 1979 for breast cancer (T2 N0M0, papillo-tubular carcinoma), was treated with ADM, TAM, and 60Co irradiation for bone metastasis in 1983. In 1984, she complained of loss of consciousness and paralysis of the extremities due to brain metastasis. After chemotherapy using ACNU (100 mg X 3), brain metastasis could not be detected on CT. She remained asymptomatic for more than 9 months without recurrence after therapy. Case 2: A 46-year-old-female, who had undergone left standard radical mastectomy in 1980 for breast cancer (T1 N1 M0, medullar tubular carcinoma), complained of headache and vertigo accompanying a hard tumor in the scalp. Chest X-ray and CT demonstrated right lung metastasis and left cerebellar metastasis. After combination chemotherapy using ACNU (100 mg) + MMC (4 mg) i.v. and FT (600 mg/day) p.o., symptoms and tumor on CT disappeared for 10 months after therapy. However, the patient died of aggravation of angina pectoris and D.M. from which she had been suffering for several years previously. These two cases correspond to complete response (CR) according to the response criteria proposed by Koyama-Saitoh.
对两例乳腺癌术后脑转移患者使用嘧啶亚硝脲（ACNU）化疗后的情况进行了评估。病例1：一名47岁女性，1979年因乳腺癌（T2 N0M0，乳头管状癌）接受了右乳标准根治术，1983年因骨转移接受了阿霉素（ADM）、他莫昔芬（TAM）和60钴照射治疗。1984年，她因脑转移出现意识丧失和肢体瘫痪。使用ACNU（100mg×3）化疗后，CT检查未发现脑转移。治疗后她无症状超过9个月且无复发。病例2：一名46岁女性，1980年因乳腺癌（T1 N1 M0，髓样管状癌）接受了左乳标准根治术，主诉头痛、眩晕，头皮有硬性肿块。胸部X线和CT显示右肺转移和左小脑转移。使用ACNU（100mg）+丝裂霉素（MMC，4mg）静脉注射和氟尿嘧啶（FT，600mg/天）口服联合化疗后，治疗后10个月症状和CT上的肿瘤消失。然而，患者死于心绞痛加重和糖尿病，她此前已患这两种疾病数年。根据小山-斋藤提出的反应标准，这两例属于完全缓解（CR）。
