Zampatti Stefania, Fabrizio Carlo, Ragazzo Michele, Campoli Giulia, Caputo Valerio, Strafella Claudia, Pellicano Clelia, Cascella Raffaella, Spalletta Gianfranco, Petrosini Laura, Caltagirone Carlo, Termine Andrea, Giardina Emiliano
Genomic Medicine Laboratory UILDM, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
J Pers Med. 2021 Aug 27;11(9):851. doi: 10.3390/jpm11090851.
The management of neuropsychiatric disorders involves different pharmacological treatments. In order to perform efficacious drug treatments, the metabolism of CYP genes can help to foresee potential drug-drug interactions. The NeuroPGx software is an open-source web-based tool for genotype/diplotype/phenotype interpretation for neuropharmacogenomic purposes. The software provides information about: (i) the genotypes of evaluated SNPs (single nucleotide polymorphisms); (ii) the main diplotypes in CYP genes and corresponding metabolization phenotypes; (iii) the list of neuropsychiatric drugs with recommended dosage adjustment (according to CPIC and DPWG guidelines); (iv) the list of possible (rare) diplotypes and corresponding metabolization phenotypes. The combined application of NeuroPGx software to the OpenArray technology results in an easy, quick, and highly automated device ready to be used in routine clinical practice.
神经精神疾病的管理涉及不同的药物治疗方法。为了进行有效的药物治疗，CYP基因的代谢情况有助于预测潜在的药物相互作用。NeuroPGx软件是一个基于网络的开源工具，用于神经药物基因组学目的的基因型/双倍型/表型解读。该软件提供以下信息：(i) 评估的单核苷酸多态性（SNP）的基因型；(ii) CYP基因中的主要双倍型及相应的代谢表型；(iii) 建议进行剂量调整的神经精神药物清单（根据CPIC和DPWG指南）；(iv) 可能的（罕见的）双倍型清单及相应的代谢表型。将NeuroPGx软件与OpenArray技术联合应用，可形成一种便于使用、快速且高度自动化的设备，随时可用于常规临床实践。
