Kurahashi Atsushi, Enomoto Toshihiko, Oguro Yoshifumi, Kojima-Nakamura Ayana, Kodaira Kazuya, Watanabe Kenichi, Ozaki Nobuhiro, Goto Hiroshi, Hirayama Masao
Hakkaisan Brewery Co., Ltd., 1051 Nagamori, Minamiuonuma City, Niigata 949-7112, Japan.
Department of Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, 754 Ichibancho, Asahimachi-dori, Chuo-ku, Niigata City, Niigata 951-8510, Japan.
J Fungi (Basel). 2021 Sep 21;7(9):782. doi: 10.3390/jof7090782.
Reportedly, the intake of , a beverage made from steamed rice fermented by , improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The had 302 ± 15.5 mg/118 g of cells, which was not in the placebo. Compared with the placebo group, the group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of and significantly increased that of at 3 weeks. Therefore, intake improved defecation frequency, and cells played potentially important roles as functional ingredients.
据报道，由[某种微生物]发酵蒸熟的大米制成的饮料[具体饮料名称]的摄入可提高排便频率。然而，其功能成分和作用机制仍不清楚。为了比较[具体饮料名称]和安慰剂饮料对排便频率的影响，并确定功能成分和作用机制，对两组进行了一项随机、安慰剂对照、双盲平行组比较试验。[具体饮料名称]每118克含有302±15.5毫克的[某种细胞]，而安慰剂中没有。与安慰剂组相比，[具体饮料名称]组在第2周（5.09天对4.14天）、第3周（5.41天对4.18天）和第4周（5.09天对3.95天）的每周排便频率显著增加，并且在第4周每周粪便重量增加（724克对501克）。[具体饮料名称]的摄入在粪便短链脂肪酸浓度方面未引起显著的组间差异，而在第3周时它显著降低了[某种微生物]的相对丰度并显著增加了[另一种微生物]的相对丰度。因此，[具体饮料名称]的摄入改善了排便频率，并且[某种细胞]作为功能成分发挥了潜在的重要作用。
