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来自[植物名称未给出]茎部的黄烷醇苷及其神经保护活性。

Flavanonol Glycosides from the Stems of and Their Neuroprotective Activities.

作者信息

Lee Hee-Ju, Park Eun-Jin, Lee Ba-Wool, Cho Hyo-Moon, Pham Thi-Linh-Giang, Hoang Quynh-Hoa, Pan Cheol-Ho, Oh Won-Keun

机构信息

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangeung 25451, Korea.

出版信息

Pharmaceuticals (Basel). 2021 Sep 9;14(9):911. doi: 10.3390/ph14090911.

DOI:10.3390/ph14090911
PMID:34577611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8472518/
Abstract

The accumulation of amyloid beta (A) peptides is common in the brains of patients with Alzheimer's disease, who are characterized by neurological cognitive impairment. In the search for materials with inhibitory activity against the accumulation of the A peptide, seven undescribed flavanonol glycosides (-) and five known compounds (-) were isolated from stems of by HPLC-qTOF MS/MS-based molecular networking. Interestingly, this plant has been used as a folk medicine for the treatment of various inflammatory conditions. The chemical structures of the isolated compounds (-) were elucidated based on spectroscopic data, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS) and electronic circular dichroism (ECD) data. Compounds , and showed neuroprotective activity against A-induced cytotoxicity in A-transfected HT22 cells.

摘要

淀粉样β（A）肽的积累在患有阿尔茨海默病的患者大脑中很常见，这些患者的特征是神经认知障碍。在寻找对A肽积累具有抑制活性的物质时，通过基于HPLC-qTOF MS/MS的分子网络从[植物名称未给出]的茎中分离出了七种未描述的黄烷醇糖苷（-）和五种已知化合物（-）。有趣的是，这种植物一直被用作治疗各种炎症的民间药物。基于光谱数据，包括一维和二维核磁共振（NMR）、高分辨率电喷雾电离质谱（HRESIMS）和电子圆二色性（ECD）数据，阐明了分离出的化合物（-）的化学结构。化合物[具体化合物编号未给出]、[具体化合物编号未给出]和[具体化合物编号未给出]在转染了A的HT22细胞中显示出对A诱导的细胞毒性的神经保护活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/3e9f98ff8a83/pharmaceuticals-14-00911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/7c0ee2e99432/pharmaceuticals-14-00911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/7535c8967a53/pharmaceuticals-14-00911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/b2cdba1f29d9/pharmaceuticals-14-00911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/32f54d4e56f2/pharmaceuticals-14-00911-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/3e9f98ff8a83/pharmaceuticals-14-00911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/7c0ee2e99432/pharmaceuticals-14-00911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/7535c8967a53/pharmaceuticals-14-00911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/b2cdba1f29d9/pharmaceuticals-14-00911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/32f54d4e56f2/pharmaceuticals-14-00911-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/725d/8472518/3e9f98ff8a83/pharmaceuticals-14-00911-g005.jpg

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3
Synergy between amyloid-β and tau in Alzheimer's disease.淀粉样蛋白-β与tau 在阿尔茨海默病中的协同作用。
Nat Neurosci. 2020 Oct;23(10):1183-1193. doi: 10.1038/s41593-020-0687-6. Epub 2020 Aug 10.
4
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J Nat Prod. 2020 Jul 24;83(7):2076-2086. doi: 10.1021/acs.jnatprod.9b00964. Epub 2020 Jun 22.
5
2020 Alzheimer's disease facts and figures.2020年阿尔茨海默病事实与数据。
Alzheimers Dement. 2020 Mar 10. doi: 10.1002/alz.12068.
6
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7
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8
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J Alzheimers Dis. 2014;41(2):615-31. doi: 10.3233/JAD-132690.
10
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