Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, 34090 Montpellier, France.
Department of Life Sciences, University of Science and Technology of Hanoi Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.
Viruses. 2021 Aug 27;13(9):1699. doi: 10.3390/v13091699.
Following repeat exposure to many human adenoviruses (HAdVs), most adults harbour long-lived B- and T-cell responses. Combined, this response typically protects us for years from re-infection by the same HAdV type. In spite of these immune responses, some HAdV types are associated with persistent infections that constitute a life-threatening risk when an individual's T-cell response is compromised. By contrast, patients with B-cell deficiencies do not appear to be at a greater risk of HAdV disease. This dichotomy begs the question of the secondary role of anti-HAdV antibodies during host defence. In this study, we explored IgG-complexed (IC)-HAdV5 and primary human plasmacytoid dendritic cell (pDC) interactions. We found that IC-HAdV5 are efficiently internalized in pDCs, stimulate their activation through TLR9 signalling, and cause apoptosis. These data may help reconcile the enigma of robust immune response to HAdVs, while concurrently allowing persistence.
在反复暴露于多种人类腺病毒（HAdV）后，大多数成年人会产生长期存在的 B 细胞和 T 细胞反应。这些反应通常可以保护我们多年免受同种 HAdV 型的再次感染。尽管存在这些免疫反应，但一些 HAdV 型与持续性感染有关，如果个体的 T 细胞反应受损，这些感染可能构成危及生命的风险。相比之下，B 细胞缺陷的患者似乎没有更高的患 HAdV 病的风险。这种二分法引出了宿主防御过程中抗 HAdV 抗体的次要作用的问题。在这项研究中，我们探讨了 IgG 复合物化（IC）-HAdV5 与原代人浆细胞样树突状细胞（pDC）的相互作用。我们发现 IC-HAdV5 可有效地被 pDC 内化，通过 TLR9 信号刺激其激活，并导致细胞凋亡。这些数据可能有助于解释对 HAdV 产生强大免疫反应的同时，又允许其持续存在的谜团。
