May Christine N, Ho Annabell Suh, Yang Qiuchen, McCallum Meaghan, Iyengar Neil M, Comander Amy, Mitchell Ellen Siobhan, Michaelides Andreas
Academic Research, Noom Inc., 229 W. 28th St., New York, NY 10001, USA.
Memorial Sloan Kettering Cancer Center, 300 East 66th St., New York, NY 10065, USA.
Nutrients. 2021 Aug 24;13(9):2908. doi: 10.3390/nu13092908.
Maintaining a healthy weight is beneficial for cancer survivors. However, weight loss program effectiveness studies have primarily been in highly controlled settings. This is a retrospective study exploring real-world outcomes (weight loss and program engagement) after use of a digital commercial weight loss program (Noom) in cancer survivors and matched controls. All participants had voluntarily self-enrolled in Noom. Weight and engagement data were extracted from the program. Cancer-related quality of life was secondarily assessed in a one-time cross-sectional survey for survivors. Controls were a sample of Noom users with overweight/obesity who had no history of cancer but 0-1 chronic conditions. Primary outcomes were weight change at 16 weeks and program engagement over 16 weeks. Engagement included frequency of weight, food, and physical activity logging, as well as number of coach messages. Multiple regression controlling for baseline age, gender, engagement, and BMI showed that survivors lost less weight than controls (B = -2.40, s.e. = 0.97, = 0.01). Survivors also weighed in less (survivors: 5.4 [2.3]; controls: 5.7 [2.1], = 0.01) and exercised less (survivors: 1.8 [3.2]; controls: 3.2 [4.1], < 0.001) than controls. However, survivors sent more coach messages (survivors: 2.1 [2.4]; controls: 1.7 [2.0], < 0.001). Despite controls losing more weight than cancer survivors (-7.0 kg vs. -5.3 kg), survivors lost significant weight in 4 months (M = -6.2%). Cancer survivors can have success on digital commercial programs available outside of a clinical trial. However, they may require additional support to engage in weight management behaviors.
保持健康体重对癌症幸存者有益。然而，减肥计划有效性研究主要是在高度受控的环境中进行的。这是一项回顾性研究，探讨了癌症幸存者和匹配对照组使用数字商业减肥计划（Noom）后的实际效果（体重减轻和计划参与度）。所有参与者均自愿自行注册使用Noom。体重和参与度数据从该计划中提取。对幸存者进行了一次性横断面调查，对癌症相关生活质量进行了二次评估。对照组是没有癌症病史但有0 - 1种慢性病的超重/肥胖Noom用户样本。主要结果是16周时的体重变化和16周内的计划参与度。参与度包括体重、食物和身体活动记录的频率，以及教练信息的数量。对基线年龄、性别、参与度和体重指数进行多元回归分析表明，幸存者比对照组体重减轻得少（B = -2.40，标准误 = 0.97，P = 0.01）。幸存者称重次数也比对照组少（幸存者：5.4 [2.3]；对照组：5.7 [2.1]，P = 0.01），锻炼次数也比对照组少（幸存者：1.8 [3.2]；对照组：3.2 [4.1]，P < 0.001）。然而，幸存者发送的教练信息更多（幸存者：2.1 [2.4]；对照组：1.7 [2.0]，P < 0.001）。尽管对照组比癌症幸存者体重减轻更多（-7.0千克对 -5.3千克），但幸存者在4个月内体重显著减轻（M = -6.2%）。癌症幸存者在临床试验之外可用的数字商业计划中也能取得成功。然而，他们可能需要额外的支持来参与体重管理行为。
