Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Department of Physiology, Faculty of Veterinary Medicine, Sadat City University, Menofia 32897, Egypt.
Nutrients. 2021 Aug 26;13(9):2973. doi: 10.3390/nu13092973.
Kaff-e-Maryam ( L.) is extensively used to treat a range of health problems, most notably to ease childbirth and alleviate reproductive system-related disorders. This study aimed to evaluate the effect of ethanolic (KEE), and aqueous (KAE) extracts on CCl-induced oxidative stress and nephrotoxicity in rats using the biochemical markers for renal functions and antioxidant status as well as histopathological examinations of kidney tissue. contained 67.49 mg GAE g of total phenolic compounds (TPC), 3.51 µg g of total carotenoids (TC), and 49.78 and 17.45 mg QE g of total flavonoids (TF) and total flavonols (TFL), respectively. It resulted in 128.71 µmol of TE g of DPPH-RSA and 141.92 µmol of TE g of ABTS-RSA. presented superior antioxidant activity by inhibiting linoleic acid radicals and chelating oxidation metals. The HPLC analysis resulted in 9 and 21 phenolic acids and 6 and 2 flavonoids in KEE and KAE with a predominance of sinapic and syringic acids, respectively. Intramuscular injection of vit. E + Se and oral administration of KEE, KAE, and KEE + KAE at 250 mg kg body weight significantly restored serum creatinine, urea, K, total protein, and albumin levels. Additionally, they reduced malondialdehyde (MOD), restored reduced-glutathione (GSH), and enhanced superoxide dismutase (SOD) levels. KEE, KAE, and KEE + KAE protected the kidneys from CCl-nephrotoxicity as they mainly attenuated induced oxidative stress. Total nephroprotection was about 83.27%, 97.62%, and 78.85% for KEE, KAE, and KEE + KAE, respectively. Both vit. E + Se and extracts attenuated the histopathological alteration in CCl-treated rats. In conclusion, , especially KAE, has the potential capability to restore oxidative stability and improve kidney function after CCl acute kidney injury better than KEE. Therefore, has the potential to be a useful therapeutic agent in the treatment of drug-induced nephrotoxicity.
玛丽安咖啡（L.）被广泛用于治疗一系列健康问题，特别是用于缓解分娩疼痛和减轻生殖系统相关疾病。本研究旨在通过生化标志物评估 CCl 诱导的氧化应激和肾毒性，以及肾组织的组织病理学检查，评估乙醇（KEE）和水提物（KAE）提取物对大鼠的影响。结果表明，KAE 中含有 67.49mg GAE/g 总酚类化合物（TPC）、3.51μg/g 总类胡萝卜素（TC）、49.78 和 17.45mg QE/g 总类黄酮（TF）和总黄烷醇（TFL），分别为 128.71μmol TE/g DPPH-RSA 和 141.92μmol TE/g ABTS-RSA。KAE 对 DPPH 和 ABTS 自由基有较强的抑制作用，具有良好的抗氧化活性。HPLC 分析结果表明，KEE 和 KAE 中分别有 9 种和 21 种酚酸以及 6 种和 2 种类黄酮，其中咖啡酸和阿魏酸分别占主导地位。肌肉注射维生素 E+硒和口服 250mg/kg 体重的 KEE、KAE 和 KEE+KAE 显著恢复了血清肌酐、尿素、钾、总蛋白和白蛋白水平。此外，它们降低了丙二醛（MOD），恢复了还原型谷胱甘肽（GSH），并增强了超氧化物歧化酶（SOD）水平。KEE、KAE 和 KEE+KAE 对肾脏具有保护作用，可减轻 CCl 诱导的氧化应激，从而减轻肾毒性。KEE、KAE 和 KEE+KAE 的总肾保护率分别约为 83.27%、97.62%和 78.85%。维生素 E+硒和提取物均能减轻 CCl 处理大鼠的组织病理学改变。综上所述，KAE 具有恢复氧化稳定性和改善 CCl 急性肾损伤后肾功能的潜力，优于 KEE。因此，KAE 具有成为治疗药物诱导性肾毒性的有效治疗剂的潜力。
Zotero 插件