Ahangar-Sirous Ramin, Poudineh Mohadeseh, Ansari Arina, Nili Ali, Dana Seyyed Mohammad Matin Alavi, Nasiri Zahra, Hosseini Zahra, Karami Dariush, Mokhtari Melika, Deravi Niloofar
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
CNS Neurol Disord Drug Targets. 2022;21(5):377-398. doi: 10.2174/1871527320666210927101257.
Age-related Neurological Disorders (ANDs) involve Neurodegenerative Diseases (NDDs), such as Alzheimer's Disease (AD), the most frequent kind of dementia in elderly people, and Parkinson's Disease (PD), and also other disorders like epilepsy and migraine. Although ANDs are multifactorial, aging is a principal risk factor for them. The common and most main pathologic features among ANDs are inflammation, oxidative stress, and misfolded proteins accumulation. Since failing brains caused by ANDs impose a notable burden on public health and their incidence is increasing, a lot of works have been conducted to overcome them. Garlic, Allium sativum, has been used for different medical purposes globally and more than thousands of publications have reported its health benefits. Garlic and aged garlic extract are considered potent anti-inflammatory and antioxidants agents and can have remarkable neuroprotective effects. This review is aimed to summarize knowledge on the pharmacotherapeutic potential of garlic and its components in ANDs.
年龄相关性神经疾病（ANDs）包括神经退行性疾病（NDDs），如阿尔茨海默病（AD），这是老年人中最常见的痴呆类型，以及帕金森病（PD），还有其他疾病，如癫痫和偏头痛。尽管ANDs是多因素导致的，但衰老却是其主要风险因素。ANDs共同且最主要的病理特征是炎症、氧化应激和错误折叠蛋白的积累。由于ANDs导致的脑功能衰退给公共卫生带来了显著负担，且其发病率不断上升，人们开展了大量工作来攻克这些疾病。大蒜，即蒜，在全球范围内被用于多种医疗目的，已有数千篇出版物报道了其对健康的益处。大蒜和陈年大蒜提取物被认为是有效的抗炎和抗氧化剂，具有显著的神经保护作用。本综述旨在总结大蒜及其成分在ANDs中的药物治疗潜力的相关知识。
