Department of Chemical, Pharmaceutical and Agricultural Sciences-DOCPAS, University of Ferrara, 44121 Ferrara, Italy.
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Int J Mol Sci. 2022 Jun 22;23(13):6950. doi: 10.3390/ijms23136950.
Garlic, , has long been utilized for a number of medicinal purposes around the world, and its medical benefits have been well documented. The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically. Garlic and garlic extracts, especially aged garlic extracts (AGEs), are rich in bioactive compounds, with potent anti-inflammatory, antioxidant and neuroprotective activities. In light of these effects, garlic and its components have been examined in experimental models of Alzheimer's disease (AD), the most common form of dementia without therapy, and a growing health concern in aging societies. With the aim of offering an updated overview, this paper reviews the chemical composition, metabolism and bioavailability of garlic bioactive compounds. In addition, it provides an overview of signaling mechanisms triggered by garlic derivatives, with a focus on allicin and AGE, to improve learning and memory.
大蒜, 在世界各地长期以来被用于多种药用目的, 其医疗益处已有充分记录。大蒜的健康益处可能源于其多种成分, 这些成分可能协同作用。大蒜和大蒜提取物, 尤其是陈蒜提取物 (AGE), 富含生物活性化合物, 具有很强的抗炎、抗氧化和神经保护作用。鉴于这些作用, 大蒜及其成分已在阿尔茨海默病 (AD) 的实验模型中进行了研究, AD 是最常见的痴呆症形式, 在老龄化社会中也是一个日益严重的健康问题。本文旨在提供最新的综述, 综述了大蒜生物活性化合物的化学组成、代谢和生物利用度。此外, 还概述了大蒜衍生物触发的信号机制, 重点介绍了大蒜素和 AGE, 以改善学习和记忆。
