Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112390. doi: 10.1016/j.msec.2021.112390. Epub 2021 Aug 25.
Post-operative recurrence and metastasis is a major challenge for breast cancer treatment. Local chemotherapy is a promising strategy that can overcome this problem. In this study, we synthesized an injectable hyaluronic acid (HA)-based hydrogel loaded with paclitaxel (PTX) nanoparticles and epirubicin (EPB) (PPNPs/EPB@HA-Gel). PPNPs/EPB@HA-Gel steadily released the encapsulated drugs to achieve long-term inhibition of tumor recurrence and metastasis in a murine post-operative breast tumor model, which prolonged their survival without any systemic toxicity. The drug-loaded hydrogel inhibited the proliferation and migration of tumor cells in vitro, and significantly increased tumor cell apoptosis in vivo. Therefore, PPNPs/EPB@HA-Gel can be used as a local chemotherapeutic agent to prevent postoperative recurrence and metastasis of breast cancer.
术后复发和转移是乳腺癌治疗的主要挑战。局部化疗是一种很有前途的策略，可以克服这个问题。在这项研究中，我们合成了一种载紫杉醇（PTX）纳米粒和表阿霉素（EPB）的可注射透明质酸（HA）水凝胶（PPNPs/EPB@HA-Gel）。PPNPs/EPB@HA-Gel 稳定地释放包封的药物，在小鼠术后乳腺癌模型中实现了对肿瘤复发和转移的长期抑制，延长了无系统毒性的存活时间。载药水凝胶在体外抑制肿瘤细胞的增殖和迁移，并显著增加体内肿瘤细胞的凋亡。因此，PPNPs/EPB@HA-Gel 可用作局部化疗药物，以预防乳腺癌术后复发和转移。
