Li Lei, Li Chun-Lei, Sun Hui-Zhuo, Yan Yue, Shi Qi, Si Dong-Xu, Wu Dong-Liang, Li You-Lin
Beijing University of Chinese Medicine Beijing 100029, China the 2nd Department of Pulmonary Disease, China-Japan Friendship Hospital, Key Unit of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea),Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with Traditional Chinese Medicine (BZ0321),Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases Beijing 100029, China.
the 2nd Department of Pulmonary Disease, China-Japan Friendship Hospital, Key Unit of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea),Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with Traditional Chinese Medicine (BZ0321),Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(17):4575-4580. doi: 10.19540/j.cnki.cjcmm.20210609.703.
This study analyzed the advantages and disadvantages of existing animal models in China and abroad and their goodness of fit based on the clinical characteristics and diagnostic criteria of stable chronic obstructive pulmonary disease(COPD) in traditional Chinese medicine(TCM) and western medicine, followed by the collation and summarization of model evaluation methodologies. The results showed that the existing animal models of stable COPD were mainly modeled via smoke exposure or the combination of multiple methods like smoke exposure plus lipopolysaccharide or protease or bacterial infection. These animal models generally failed to simulate the clinical characteristics of TCM, and their goodness of fit in western medicine was higher than that in TCM. There is a lack of research on the animal models of stable COPD and the disease-syndrome combination models. Although the modeling is guided by the pathogenesis or mechanism of diseased humans, the established models were still not identical with the actual clinical situations. In-depth research is needed to develop quantitative standards for stable COPD models.
本研究基于中医和西医对稳定期慢性阻塞性肺疾病（COPD）的临床特征及诊断标准，分析了国内外现有动物模型的优缺点及其拟合优度，随后对模型评价方法进行了整理和总结。结果表明，现有的稳定期COPD动物模型主要通过烟熏暴露或多种方法联合建模，如烟熏暴露加脂多糖或蛋白酶或细菌感染。这些动物模型一般未能模拟中医的临床特征，其在西医方面的拟合优度高于中医。目前缺乏对稳定期COPD动物模型及病证结合模型的研究。虽然建模以患病人类的发病机制或机理为指导，但所建立的模型仍与实际临床情况不一致。需要深入研究以制定稳定期COPD模型的量化标准。
