Wu Rui, Li Xiu-Min, Miao Ming-San
Henan University of Chinese Medicine Zhengzhou 450046,China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(4):782-785. doi: 10.19540/j.cnki.cjcmm.20200918.601.
Based on the characteristics of clinical symptoms of chronic skin ulcers in traditional Chinese and Western medicine, the current animal models of skin ulcers are summarized. This article analyzes the advantages and disadvantages of animal models according to the etiology and pathogenesis of chronic skin ulcers, traditional Chinese and Western medicine diagnostic criteria and observation indicators, and eva-luates the agreement between the existing animal models and the characteristics of clinical syndromes of traditional Chinese and Western medicine for chronic skin ulcers. Through analysis and comparison, it is found that most of the existing modeling methods are single-factor animal models, and there are certain gaps in the physiological and pathological characteristics of chronic skin ulcers caused by clinical multi-factors and interactions. Most of the modeling methods are guided by Western medicine. The lack of pathogenic factors of traditional Chinese medicine(TCM) in the process of modeling. Therefore, this article proposes to establish a reasonable quantification standard for chronic skin ulcer animal models, and to establish a combination model of chronic skin ulcer disease with traditional Chinese and Western medicine as the focus of future animal model research.
基于中西医对慢性皮肤溃疡临床症状的特点，对目前皮肤溃疡动物模型进行总结。本文根据慢性皮肤溃疡的病因病机、中西医诊断标准及观察指标分析动物模型的优缺点，并评估现有动物模型与慢性皮肤溃疡中西医临床证候特点的契合度。通过分析比较发现，现有建模方法多为单因素动物模型，临床多因素及相互作用所致慢性皮肤溃疡的生理病理特征存在一定差距。多数建模方法以西医为导向，建模过程中缺乏中医致病因素。因此，本文提出建立慢性皮肤溃疡动物模型合理的量化标准，并以建立中西医结合的慢性皮肤溃疡疾病模型作为未来动物模型研究重点。
