染料功能化的磷酸结合大环：从核苷酸到 G-四链体识别和“开启”荧光传感。
Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and "turn-on" fluorescence sensing.
机构信息
Department of Chemistry and Pharmacy, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany.
Institute of Chemistry, Technische Universität Chemnitz, 09107 Chemnitz, Germany.
出版信息
Chem Commun (Camb). 2021 Oct 12;57(81):10632-10635. doi: 10.1039/d1cc04096k.
PMID:34581337
Abstract
A novel strategy to design "turn-on" fluorescent receptors for G-quadruplexes of DNA is presented, which relies on the connection of phosphate binding macrocycles (PBM) with naphthalimide dyes. A new PBM-dye family was synthesized and evaluated in terms of binding and detection of nucleotides and DNA G-quadruplexes of different topologies.
摘要
本文提出了一种设计用于 DNA G-四链体的“开启”型荧光受体的新策略，该策略依赖于将磷酸结合大环（PBM）与萘酰亚胺染料连接。本文合成了一个新的 PBM-染料家族，并对其结合和检测不同拓扑结构的核苷酸和 DNA G-四链体的性能进行了评估。
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