Liu Yubo, Chen Xiaohong, Yu Deng-Guang, Liu Hang, Liu Yuyang, Liu Ping
School of Materials Science & Engineering, University of Shanghai for Science & Technology, Shanghai 200093, China.
Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials, Shanghai 200093, China.
Mol Pharm. 2021 Nov 1;18(11):4170-4178. doi: 10.1021/acs.molpharmaceut.1c00559. Epub 2021 Sep 28.
Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant challenge in the drug delivery system. As a novel solution, core-shell nanodrug containers have aroused many interests due to their potential improvement in drug-sustained release. In this work, a biodegradable polymer, poly(3-hydroxybutyrate--3-hydroxyvalerate) (PHBV), and hydrophilic polyvinylpyrrolidone (PVP) were exploited as drug delivery carriers by coaxial electrospinning, and the core-shell drug-loaded fibers exhibited improved sustained release of Cur. A cylindrical morphology and a clear core-shell structure were observed by scanning and transmission electron microscopies. The X-ray diffraction pattern and infrared spectroscopy revealed that Cur existed in amorphous form due to its good compatibility with PHBV and PVP. The in vitro drug release curves confirmed that the core-shell container manipulated Cur in a faster drug release process than that in the traditional PHBV monolithic container. The combination of the material and structure forms a novel nanodrug container with a better sustained release of water-insoluble Cur. This strategy is beneficial for exploiting more functional biomedical materials to improve the drug release behavior.
在水不溶性姜黄素（Cur）的缓释中实现药物释放的逐渐减少是药物递送系统中的一项重大挑战。作为一种新颖的解决方案，核壳纳米药物载体因其在药物缓释方面的潜在改进而引起了诸多关注。在这项工作中，通过同轴静电纺丝利用可生物降解聚合物聚（3-羟基丁酸酯-3-羟基戊酸酯）（PHBV）和亲水性聚乙烯吡咯烷酮（PVP）作为药物递送载体，载药的核壳纤维表现出改善的Cur缓释性能。通过扫描电子显微镜和透射电子显微镜观察到圆柱形形态和清晰的核壳结构。X射线衍射图谱和红外光谱表明，由于Cur与PHBV和PVP具有良好的相容性，其以无定形形式存在。体外药物释放曲线证实，核壳载体在药物释放过程中对Cur的控制比传统的PHBV整体载体更快。材料与结构的结合形成了一种新型纳米药物载体，对水不溶性Cur具有更好的缓释性能。该策略有利于开发更多功能性生物医学材料以改善药物释放行为。
