水蛭神经系统中的节段分化：与异位靶标相关的特定表型变化。

Macagno E R, Peinado A, Stewart R R

Proc Natl Acad Sci U S A. 1986 Apr;83(8):2746-50. doi: 10.1073/pnas.83.8.2746.

The issue of whether interactions between central neurons and the targets they innervate are involved in establishing segment-specific phenotypic differences in the central nervous system was evaluated by studying the effect of naturally occurring ectopic targets on individual identified neurons of the leech Hirudo medicinalis. The specimens studied were found to have additional sex organs located in segments adjacent to those containing the normal structures. We report our observations on neuronal morphology, the presence or absence of specific neurons, and total ganglionic cell number and discuss some of the possible ways in which the observed changes might have arisen.

通过研究水蛭（Hirudo medicinalis）中自然出现的异位靶标对单个已识别神经元的影响，评估了中枢神经元与其所支配的靶标之间的相互作用是否参与建立中枢神经系统中节段特异性表型差异这一问题。研究的标本被发现有额外的性器官，位于与包含正常结构的节段相邻的节段中。我们报告了关于神经元形态、特定神经元的有无以及神经节细胞总数的观察结果，并讨论了观察到的变化可能出现的一些可能方式。