Castillo-Mancilla Jose R, Morrow Mary, Coyle Ryan P, Coleman Stacey S, Zheng Jia-Hua, Ellison Lucas, Bushman Lane R, Kiser Jennifer J, Anderson Peter L, MaWhinney Samantha
Division of Infectious Diseases, School of Medicine, University of Colorado-AMC, Aurora, Colorado, USA.
Department of Biostatistics and Bioinformatics, Colorado School of Public Health, Aurora, Colorado, USA.
Open Forum Infect Dis. 2021 Sep 17;8(9):ofab463. doi: 10.1093/ofid/ofab463. eCollection 2021 Sep.
The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate-containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800-1650; 800-1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2-3.1), 2.4 (95% CI, 1.1-5.0), and 4.6 (95% CI, 2.2-9.9), respectively. This suggests that adherence could impact LLV.
20至200拷贝/毫升之间的低水平病毒血症（LLV）驱动因素仍不清楚。在497名接受含富马酸替诺福韦二吡呋酯抗逆转录病毒治疗（ART）的艾滋病毒感染者的1042人次就诊中，评估了LLV与累积抗逆转录病毒依从性（使用干血斑中的替诺福韦二磷酸[TFV-DP]进行量化）之间的关联。较低的TFV-DP水平与LLV的较高几率相关。随着TFV-DP（fmol/打孔）类别从>1650降至800-1650；800-1650降至<800；以及>1650降至<800，LLV与HIV病毒载量<20拷贝/毫升相比的调整优势比分别为2.0（95%CI，1.2-3.1）、2.4（95%CI，1.1-5.0）和4.6（95%CI，2.2-9.9）。这表明依从性可能会影响LLV。
