Section of Sensory Science & Metabolism (SenSMet), National Institute on Alcohol Abuse & Alcoholism & National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Psychiatry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Epigenomics. 2021 Sep;13(18):1485-1496. doi: 10.2217/epi-2021-0192. Epub 2021 Sep 29.
To investigate the association between placental genome-wide methylation at birth and antenatal depression and stress during pregnancy. We examined the association between placental genome-wide DNA methylation (n = 301) and maternal depression and stress assessed at six gestation periods during pregnancy. Correlation between DNA methylation at the significantly associated CpGs and expression of nearby genes in the placenta was tested. Depression and stress were associated with methylation of 16 CpGs and two CpGs, respectively, at a 5% false discovery rate. Methylation levels at two of the CpGs associated with depression were significantly associated with expression of and , genes implicated in neurodevelopment and neuropsychiatric diseases. Placental epigenetic changes linked to antenatal depression suggest potential fetal brain programming. Clinical trial registration number: NCT00912132 (ClinicalTrials.gov).
探讨出生时胎盘全基因组甲基化与产前抑郁和孕期压力的关系。我们研究了胎盘全基因组 DNA 甲基化（n=301）与在孕期 6 个时期评估的母亲抑郁和压力之间的关联。测试了在显著相关的 CpG 处的 DNA 甲基化与胎盘附近基因表达之间的相关性。在 5%的错误发现率下，抑郁和压力分别与 16 个 CpG 和两个 CpG 的甲基化有关。与抑郁相关的两个 CpG 的甲基化水平与 和 基因的表达显著相关，这些基因涉及神经发育和神经精神疾病。与产前抑郁相关的胎盘表观遗传变化表明潜在的胎儿大脑编程。临床试验注册号：NCT00912132（ClinicalTrials.gov）。
