The Bio21 Institute of Molecular Science and Biotechnology, Melbourne Dental School, Centre for Oral Health Research, University of Melbourne, Melbourne, Victoria 3010, Australia.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
ACS Infect Dis. 2021 Nov 12;7(11):2959-2970. doi: 10.1021/acsinfecdis.1c00424. Epub 2021 Sep 30.
Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highest incidence. Caries and periodontal disease arise from infections caused by oral bacterial pathogens. Current misuse and overuse of antibiotic treatments have led to the development of antimicrobial resistance. However, recent studies have shown that cationic antimicrobial peptides are a promising family of antibacterial agents that are active against oral pathogenic bacteria and also possess less propensity for development of antimicrobial resistance. This timely Review has a focus on two primary subjects: (i) the oral bacterial pathogens associated with dental infections and (ii) the current development of antimicrobial peptides targeting oral pathogens.
口腔牙科感染是影响人类的最常见疾病之一，其中龋齿和牙周病的发病率最高。龋齿和牙周病是由口腔细菌病原体引起的感染引起的。目前，抗生素治疗的滥用和过度使用导致了抗微生物药物耐药性的产生。然而，最近的研究表明，阳离子抗菌肽是一类很有前途的抗菌剂家族，对口腔致病菌具有活性，而且不易产生抗微生物药物耐药性。这篇及时的综述主要关注两个主题：（i）与牙科感染相关的口腔细菌病原体；（ii）针对口腔病原体的抗菌肽的当前发展。
