Liu Ziyu, Tamaddon Maryam, Chen Shen-Mao, Wang Haoyu, San Cheong Vee, Gang Fangli, Sun Xiaodan, Liu Chaozong
Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, London, United Kingdom.
School of Engineering Medicine, Beihang University, Beijing, China.
Front Bioeng Biotechnol. 2021 Sep 13;9:736063. doi: 10.3389/fbioe.2021.736063. eCollection 2021.
For achieving early intervention treatment to help patients delay or avoid joint replacement surgery, a personalized scaffold should be designed coupling the effects of mechanical, fluid mechanical, chemical, and biological factors on tissue regeneration, which results in time- and cost-consuming trial-and-error analyses to investigate the test and related experimental tests. To optimize the fluid mechanical and material properties to predict osteogenesis and cartilage regeneration for the and clinical trial, a simulation approach is developed for scaffold design, which is composed of a volume of a fluid model for simulating the bone marrow filling process of the bone marrow and air, as well as a discrete phase model and a cell impingement model for tracking cell movement during bone marrow fillings. The bone marrow is treated as a non-Newtonian fluid, rather than a Newtonian fluid, because of its viscoelastic property. The simulation results indicated that the biofunctional bionic scaffold with a dense layer to prevent the bone marrow flow to the cartilage layer and synovia to flow into the trabecular bone area guarantee good osteogenesis and cartilage regeneration, which leads to high-accuracy tests in sheep . This approach not only predicts the final bioperformance of the scaffold but also could optimize the scaffold structure and materials by their biochemical, biological, and biomechanical properties.
为实现早期干预治疗以帮助患者推迟或避免关节置换手术，应设计一种个性化支架，将机械、流体力学、化学和生物学因素对组织再生的影响结合起来，这会导致耗时且成本高昂的反复试验分析，以研究测试和相关实验测试。为优化流体力学和材料特性，以预测骨生成和软骨再生用于前期试验和临床试验，开发了一种用于支架设计的模拟方法，该方法由一个用于模拟骨髓和空气的骨髓填充过程的流体模型体积，以及一个离散相模型和一个用于跟踪骨髓填充过程中细胞运动的细胞撞击模型组成。由于骨髓的粘弹性特性，将其视为非牛顿流体，而非牛顿流体。模拟结果表明，具有致密层以防止骨髓流向软骨层和滑膜流入小梁骨区域的生物功能仿生支架可保证良好的骨生成和软骨再生，这在绵羊身上实现了高精度的前期试验。这种方法不仅可以预测支架的最终生物性能，还可以通过其生化、生物学和生物力学特性优化支架结构和材料。
