Kordansky D, Adkinson N F, Norman P S, Rosenthal R R
Ann Intern Med. 1978 Apr;88(4):508-11. doi: 10.7326/0003-4819-88-4-508.
A patient who claimed benefit from aspirin for her reversible bronchospasm was challenged orally in a placebo-controlled study with aspirin and other aspirin-like drugs. Specific airways conductance and spirometry were monitored for up to 150 minutes after oral challenge. Aspirin, mefenamic acid, and ibuprofen administration resulted in marked (45% to 80%) improvement in forced expiratory volume in 1 second (FEV1) compared to lactose placebo. Indomethacin, sodium salicylate, and tartrazine resulted in modest (15% to 25%) FEV1 improvement, while phenylbutazone produced a 25% decrease. These results are discussed here in terms of the ability of these drugs to inhibit the prostaglandin synthetase enzyme system. This case suggests that aspirin and other nonsteroidal anti-inflammatory drugs may be beneficial rather than harmful in some asthmatic patients.
一名称服用阿司匹林后可逆性支气管痉挛症状得到缓解的患者，在一项安慰剂对照研究中接受了阿司匹林及其他类阿司匹林药物的口服激发试验。口服激发试验后长达150分钟内监测特定气道传导率和肺量测定值。与乳糖安慰剂相比，服用阿司匹林、甲芬那酸和布洛芬后1秒用力呼气量（FEV1）显著改善（45%至80%）。吲哚美辛、水杨酸钠和酒石黄使FEV1适度改善（15%至25%），而保泰松则使FEV1下降了25%。本文根据这些药物抑制前列腺素合成酶酶系统的能力对这些结果进行了讨论。该病例表明，阿司匹林和其他非甾体抗炎药在某些哮喘患者中可能有益而非有害。
