镇痛药、过敏与哮喘。
Analgesics, allergy and asthma.
作者信息
Szczeklik A
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):401S-405S. doi: 10.1111/j.1365-2125.1980.tb01830.x.
Abstract
1 Recent studies of idiosyncratic reactions to analgesics have revealed several clinical patterns with a different pathogenesis. 2 In the pathogenesis of a common type of asthma precipitated by aspirin, inhibition of cyclooxygenase leading to disturbances in metabolism of arachidonic acid is of fundamental importance. 3 In some patients with urticaria/angioedema, symptoms are due to inhibition of cyclo-oxygenase by analgesics; in others the cause might be impurities in commercial preparations of aspirin; and in others the mechanisms are still unknown. 4 There is a distinct group of patients who develop anaphylactic shock or urticaria following administration of pyrazolone drugs, but who tolerate aspirin and other cyclo-oxygenase inhibitors. This type of hypersensitivity seems to have an immunological background.
摘要
- 近期关于镇痛药特异反应的研究揭示了几种具有不同发病机制的临床模式。2. 在由阿司匹林诱发的一种常见哮喘类型的发病机制中，环氧化酶的抑制导致花生四烯酸代谢紊乱至关重要。3. 在一些荨麻疹/血管性水肿患者中，症状是由镇痛药对环氧化酶的抑制引起的；在另一些患者中，病因可能是阿司匹林商业制剂中的杂质；还有一些患者的发病机制仍不清楚。4. 有一组独特的患者，在服用吡唑酮类药物后会发生过敏性休克或荨麻疹，但能耐受阿司匹林和其他环氧化酶抑制剂。这种超敏反应类型似乎具有免疫背景。
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引用本文的文献
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The clinical assessment of analgesic drugs.镇痛药的临床评估。
Br J Clin Pharmacol. 1981 Apr;11(4):319-32. doi: 10.1111/j.1365-2125.1981.tb01128.x.
2
Asthma and anti-inflammatory drugs. Mechanisms and clinical patterns.哮喘与抗炎药物。作用机制与临床模式。
Drugs. 1983 Jun;25(6):533-43. doi: 10.2165/00003495-198325060-00001.
3
Adverse drug reactions leading to hospital admission.
Drug Saf. 1991 Nov-Dec;6(6):450-9. doi: 10.2165/00002018-199106060-00005.
本文引用的文献
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Intolerance to aspirin. Clinical studies and consideration of its pathogenesis.阿司匹林不耐受。临床研究及其发病机制的探讨
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Immunological effects of aspirin anhydride, a contaminant of commercial acetylsalicylic acid preparations.市售乙酰水杨酸制剂的污染物——阿司匹林酸酐的免疫学效应。
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Challenge test battery in chronic urticaria.
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Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.镇痛药对前列腺素生物合成的抑制作用与阿司匹林敏感患者哮喘发作的关系。
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Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias.
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