Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Drug Dev Ind Pharm. 2021 Jul;47(7):1029-1037. doi: 10.1080/03639045.2021.1988097. Epub 2021 Oct 11.
The nanotechnology approach has been recently adopted to provide more reliable, effective, controlled, and safe drug delivery systems. Nanostructured materials have gained great interest, including siliceous and carbonaceous nanoparticles. The effectiveness of mesoporous carbon nanoparticles (MCNs) in tumor imaging, targeting, and treatment is urging for more future studies. MCNs possess superior properties such as their biocompatibility, large surface area, large pore volume, tunability, and more responsive behavior to internal and external release triggers. These outstanding features make MCNs more applicable for stimuli-responsive drug delivery than the conventional forms of mesoporous silica nanoparticles (MSNs) and other carbon nanoparticles. In this review, we outlined the latest updates regarding the safety, benefits, and potential applications of MCNs.
纳米技术方法最近被采用，以提供更可靠、有效、可控和安全的药物传递系统。包括硅质和碳质纳米粒子在内的纳米结构材料引起了广泛关注。介孔碳纳米粒子（MCNs）在肿瘤成像、靶向和治疗方面的有效性促使人们对其进行更多的未来研究。MCNs 具有优越的性能，如生物相容性、大表面积、大孔体积、可调节性以及对内部和外部释放触发的更响应性。这些卓越的特性使得 MCNs 比传统形式的介孔硅纳米粒子（MSNs）和其他碳纳米粒子更适用于刺激响应性药物传递。在这篇综述中，我们概述了 MCNs 的最新安全性、益处和潜在应用的更新信息。
