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介孔材料作为抗炎药物现代给药系统的组成部分:近期成果综述

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements.

作者信息

Moritz Michał, Geszke-Moritz Małgorzata

机构信息

Department of Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Plac Polskiego Czerwonego Krzyża 1, 71-251 Szczecin, Poland.

Department of Pharmacognosy and Natural Medicines, Pomeranian Medical University in Szczecin, Plac Polskiego Czerwonego Krzyża 1, 71-251 Szczecin, Poland.

出版信息

Pharmaceutics. 2022 Jul 25;14(8):1542. doi: 10.3390/pharmaceutics14081542.

Abstract

Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

摘要

在过去二十年中,人们对使用介孔材料作为药物载体的兴趣一直在稳步增长。介孔载体可应用于制备来自各种治疗组的药物递送系统;然而,它们作为抗炎剂载体的应用尤为显著。这篇综述文章引用了约170篇参考文献,总结了近年来介孔材料作为抗炎剂载体应用方面的成果。本文将讨论各种介孔载体及其多孔结构的特性,这些特性决定了这些材料在医学应用领域的进一步应用。将特别关注在构建刺激响应性药物载体和提供定点药物递送的系统方面所取得的进展。随后,对有关使用介孔基质作为抗炎药物载体的文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689a/9331996/a576dc940bba/pharmaceutics-14-01542-g001.jpg

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