Department of Cardiology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
Department of Cardiology, Yozgat City Hospital, Yozgat Turkey.
Turk J Med Sci. 2021 Dec 13;51(6):3030-3037. doi: 10.3906/sag-2105-177.
BACKGROUND/AIM: Hypertensive patients have shown autonomic dysfunction that is closely associated with the measurements of heart rate variability (HRV) and heart rate turbulence (HRT). We aimed to show the alterations of HRV and HRT measurements in patients with both dipper and non-dipper hypertension.
This was a retrospective study consisting of one hundred and twenty-three participants (mean age ± SD, 55.7 ± 14.8 years; range, 18–90 years). The participants were divided into two groups: Group1: The patients with dipper hypertension, Group2: The patients with non-dipper hypertension. Two cardiologists performed HRV and HRT using 24-h electrocardiography (ECG) Holter and ambulatory blood pressure monitoring (ABPM) of patients.
The results indicated that patients in group 2 had higher low frequency power/high frequency power ratio (LF/HF), lower high frequency power (HF) , root mean square of standard deviation (RMSSD) values than group 1 (p = 0.007, p = 0.008, and p = 0.002, respectively). Group 2 also showed higher heart rate turbulence onset (HRTTO) and lower heart rate turbulence slope (HRTTS) values than Group 1 (p = 0.004, p = 0.001, respectively). We performed multivariate analysis and observed that HRTTS and HRTTO have statistically significant associations with the presence of dipper or non-dipper hypertension [F = 7.755, p = 0.001], LF/HF [F = 7.868, p = 0.001], and HF [F = 4.081, p = 0.020].
This study shows a statistically significant difference in HRT measurements between dipper and non-dipper hypertensive patients. Deteriorated autonomic circadian rhythm and autonomic functions may contribute to these results.
背景/目的：高血压患者表现出自主神经功能障碍，这与心率变异性（HRV）和心率震荡（HRT）的测量密切相关。我们旨在展示杓型和非杓型高血压患者的 HRV 和 HRT 测量变化。
这是一项回顾性研究，共纳入 123 名参与者（平均年龄 ± 标准差，55.7 ± 14.8 岁；范围 18-90 岁）。参与者分为两组：组 1：杓型高血压患者，组 2：非杓型高血压患者。两名心脏病专家使用 24 小时心电图（ECG）动态心电图和动态血压监测（ABPM）对患者进行 HRV 和 HRT。
结果表明，组 2 患者的低频功率/高频功率比（LF/HF）较高，高频功率（HF）较低，均方根标准差（RMSSD）值低于组 1（p=0.007，p=0.008 和 p=0.002，分别）。组 2 的心率震荡起始（HRTTO）也高于组 1，心率震荡斜率（HRTTS）低于组 1（p=0.004，p=0.001，分别）。我们进行了多元分析，观察到 HRTTS 和 HRTTO 与杓型或非杓型高血压的存在具有统计学显著关联[F=7.755，p=0.001]，LF/HF [F=7.868，p=0.001]和 HF [F=4.081，p=0.020]。
本研究显示杓型和非杓型高血压患者的 HRT 测量存在统计学显著差异。自主昼夜节律和自主功能恶化可能导致这些结果。
