Holdener-Kenny B, Weaver S
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4374-8. doi: 10.1073/pnas.83.12.4374.
A restriction fragment size difference of 1.9 kilobases exists between the C57BL/10 (Hbbs) and BALB/c (Hbbd) beta-globin gene clusters in the vicinity of the Hbb-y and Hbb-bh0 genes. This length difference is the result of a deletion that removes the majority of the C57BL/10 Hbb-bh0 gene. The Hbb-bh0 deletion appears to be widespread among Hbbs-carrying mice. In addition to the deletion, 119 base pairs of DNA of unknown origin are found in C57BL/10 DNA at the point of discontinuity. The existence of this deletion is inconsistent with reports of transcripts homologous to the third exon of the Hbb-bh0 gene in both C57BL/10 embryos and in a cell line carrying the Hbbs haplotype. We propose that the Hbb-bh0 gene is a recently disabled pseudogene.
在Hbb - y和Hbb - bh0基因附近，C57BL / 10（Hbbs）和BALB / c（Hbbd）β - 珠蛋白基因簇之间存在1.9千碱基的限制性片段大小差异。这种长度差异是由于一次缺失导致的，该缺失去除了C57BL / 10 Hbb - bh0基因的大部分。Hbb - bh0缺失似乎在携带Hbbs的小鼠中广泛存在。除了该缺失外，在C57BL / 10 DNA的间断点处发现了119个碱基对的未知来源DNA。此缺失的存在与关于C57BL / 10胚胎和携带Hbbs单倍型的细胞系中与Hbb - bh0基因第三外显子同源转录本的报道不一致。我们认为Hbb - bh0基因是一个最近失活的假基因。
