与小鼠基因组中长散在核元件相关的染色体重排。
Chromosomal rearrangements associated with LINE elements in the mouse genome.
作者信息
Shyman S, Weaver S
出版信息
Nucleic Acids Res. 1985 Jul 25;13(14):5085-93. doi: 10.1093/nar/13.14.5085.
Abstract
Two segments of DNA that have apparently inserted in the interval between the two adult beta-globin genes in BALB/c (Hbbd haplotype) but not in C57B1/10 (Hbbs haplotype) mouse strains have been described (1). These putative insertions, each about 1000 bp in length, mapped near a repetitive element. To determine the precise position of these alleged insertions, their target sites, and the nature of their boundaries, we cloned and sequenced the appropriate regions of both chromosomes. One of the two segments is not an insertion but rather a region between two independently integrated L1 repetitive elements (LINEs) (2), one in Hbbd and the other in the Hbbs chromosome. The other segment is an insertion of 940 bp which is located within the L1 element in the Hbbd chromosome. This insert is unusual in that it exists in only one copy in the BALB/c genome.
摘要
已经描述了两段DNA，它们明显插入到BALB/c（Hbbd单倍型）小鼠品系的两个成年β-珠蛋白基因之间的区间，但未插入到C57B1/10（Hbbs单倍型）小鼠品系中（1）。这些假定的插入片段，每个长度约为1000 bp，定位在一个重复元件附近。为了确定这些所谓插入片段的精确位置、它们的靶位点以及其边界的性质，我们克隆并测序了两条染色体的相应区域。两段中的一段不是插入片段，而是两个独立整合的L1重复元件（长散在核元件）之间的一个区域（2），一个在Hbbd染色体中，另一个在Hbbs染色体中。另一段是940 bp的插入片段，位于Hbbd染色体的L1元件内。这个插入片段不同寻常之处在于它在BALB/c基因组中仅以一个拷贝存在。
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本文引用的文献
1
Structure, variation and synthesis of retrovirus long terminal repeat.逆转录病毒长末端重复序列的结构、变异与合成
Cell. 1981 Nov;27(1 Pt 2):1-3. doi: 10.1016/0092-8674(81)90353-6.
2
The adult beta-globin genes of the "single" type mouse C57BL.“单一”型小鼠C57BL的成年β-珠蛋白基因
Cell. 1981 May;24(2):403-11. doi: 10.1016/0092-8674(81)90330-5.
3
Dispersal process associated with the L1 family of interspersed repetitive DNA sequences.与散布重复DNA序列L1家族相关的扩散过程。
J Mol Biol. 1984 Oct 5;178(4):795-813. doi: 10.1016/0022-2836(84)90312-7.
4
Ubiquitous transposon-like repeats B1 and B2 of the mouse genome: B2 sequencing.小鼠基因组中普遍存在的类转座子重复序列B1和B2：B2测序
Nucleic Acids Res. 1982 Dec 11;10(23):7461-75. doi: 10.1093/nar/10.23.7461.
5
Transposition of cloned P elements into Drosophila germ line chromosomes.克隆的P因子向果蝇种系染色体的转座。
Science. 1982 Oct 22;218(4570):341-7. doi: 10.1126/science.6289435.
6
New rapid methods for DNA sequencing based in exonuclease III digestion followed by repair synthesis.基于核酸外切酶III消化后进行修复合成的新型DNA测序快速方法。
Nucleic Acids Res. 1982 Mar 25;10(6):2065-84. doi: 10.1093/nar/10.6.2065.
7
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8
SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes.短散在重复序列和长散在重复序列：哺乳动物基因组中高度重复的短散在和长散在序列
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9
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10
Insertion of the Drosophila transposable element copia generates a 5 base pair duplication.果蝇转座因子copia的插入会产生一个5个碱基对的重复序列。
Cell. 1980 Sep;21(2):575-9. doi: 10.1016/0092-8674(80)90495-x.
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