Weaver S, Haigwood N L, Hutchison C A, Edgell M H
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1385-9. doi: 10.1073/pnas.76.3.1385.
Two alternative haplotypes at the complex locus controlling hemoglobin beta chain synthesis in Mus musculus were compared at the DNA level. As expected, Hbbd homozygotes--which as adults synthesize two species of beta chain--have two genes for beta globin. Adult mice homozygous for the Hbbs haplotype make only a single type of beta polypeptide, yet they also have two beta globin genes. Apparently the two Hbbs genes encode identical proteins, or one of the two genes is not detectably expressed. The Hbbs and Hbbd haplotypes are thus more similar at the DNA level than studies of their polypeptide products have indicated.
在小家鼠中，对控制血红蛋白β链合成的复合基因座上的两种替代单倍型进行了DNA水平的比较。正如预期的那样，Hbbd纯合子——成年后合成两种β链——有两个β珠蛋白基因。Hbbs单倍型的成年纯合小鼠只产生一种类型的β多肽，但它们也有两个β珠蛋白基因。显然，这两个Hbbs基因编码相同的蛋白质，或者这两个基因中的一个没有可检测到的表达。因此，Hbbs和Hbbd单倍型在DNA水平上比它们多肽产物的研究所显示的更为相似。
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