头孢替安联合用药对中度敏感或对这种新型头孢菌素耐药的肠杆菌科细菌的抗菌活性。
Antimicrobial activity of cefotiam combinations against Enterobacteriaceae moderately susceptible or resistant to this new cephalosporin.
作者信息
Husson M O, Izard D, Leclerc H
出版信息
Drugs Exp Clin Res. 1986;12(4):325-7.
The interaction of cefotiam with each of the four aminoglycosides gentamicin, tobramycin, netilmicin and amikacin were studied by the broth microdilution method ("checkerboard" technique) against 36 strains of Enterobacteriaceae chosen for their moderate susceptibility (MIC: 4-32 mg/l) or resistance (MIC: 64-512 mg/l) to cefotiam. A high rate of synergistic combinations was found with all the aminoglycosides: 81% with gentamicin, 76% with amikacin, 67% with tobramycin and netilmicin. The therapeutic value of these interactions appeared excellent.
采用肉汤微量稀释法（“棋盘”技术），研究了头孢替安与庆大霉素、妥布霉素、奈替米星和阿米卡星这四种氨基糖苷类药物对36株肠杆菌科细菌的相互作用。这些菌株对头孢替安具有中度敏感性（MIC：4-32mg/l）或耐药性（MIC：64-512mg/l）。结果发现，头孢替安与所有氨基糖苷类药物联合使用时均有较高比例的协同组合：与庆大霉素为81%，与阿米卡星为76%，与妥布霉素和奈替米星为67%。这些相互作用的治疗价值似乎极佳。
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