Husson M O, Izard D, Leclerc H
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):466-8.
Antibacterial activity of cefotiam associated with gentamicin, tobramycin, netilmicin, or amikacin against Enterobacteriaceae strains either moderately susceptible (MIC = 4 to 32 micrograms/ml, 14 strains) or resistant (MIC = 64 to 512 micrograms/ml, 22 strains) to cefotiam was studied using the checkerboard method. High rates of synergic associations (FIC index less than or equal to 0.5) were found, with variations according to the aminoglycoside: 65% for tobramycin and netilmicin, 76% for amikacin, and 81% for gentamicin. Activity of cefotiam is increased by the synergic effect of these associations: of the 36 strains tested, 83, 78 and 76% became susceptible to cefotiam (MIC less than or equal to 4 micrograms/ml) associated with tobramycin, netilmicin or gentamicin, and amikacin respectively.
采用棋盘法研究了头孢替安与庆大霉素、妥布霉素、奈替米星或阿米卡星联合对中度敏感（MIC=4至32微克/毫升，14株）或对头孢替安耐药（MIC=64至512微克/毫升，22株）的肠杆菌科菌株的抗菌活性。发现协同组合率较高（FIC指数小于或等于0.5），且根据氨基糖苷类药物不同而有所变化：妥布霉素和奈替米星为65%，阿米卡星为76%，庆大霉素为81%。这些联合的协同作用增强了头孢替安的活性：在测试的36株菌株中，分别与妥布霉素、奈替米星、庆大霉素或阿米卡星联合时，83%、78%和76%的菌株对头孢替安敏感（MIC小于或等于4微克/毫升）。
