头孢替安-氨基糖苷类药物联合使用对头孢菌素低敏感性菌株协同作用的体外研究

[In vitro study of the synergistic effect of cefotiam- aminoglycoside combinations on strains of low susceptibility to this cephalosporin].

作者信息

Husson M O, Izard D, Leclerc H

出版信息

Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):466-8.

Abstract

Antibacterial activity of cefotiam associated with gentamicin, tobramycin, netilmicin, or amikacin against Enterobacteriaceae strains either moderately susceptible (MIC = 4 to 32 micrograms/ml, 14 strains) or resistant (MIC = 64 to 512 micrograms/ml, 22 strains) to cefotiam was studied using the checkerboard method. High rates of synergic associations (FIC index less than or equal to 0.5) were found, with variations according to the aminoglycoside: 65% for tobramycin and netilmicin, 76% for amikacin, and 81% for gentamicin. Activity of cefotiam is increased by the synergic effect of these associations: of the 36 strains tested, 83, 78 and 76% became susceptible to cefotiam (MIC less than or equal to 4 micrograms/ml) associated with tobramycin, netilmicin or gentamicin, and amikacin respectively.

摘要

采用棋盘法研究了头孢替安与庆大霉素、妥布霉素、奈替米星或阿米卡星联合对中度敏感（MIC=4至32微克/毫升，14株）或对头孢替安耐药（MIC=64至512微克/毫升，22株）的肠杆菌科菌株的抗菌活性。发现协同组合率较高（FIC指数小于或等于0.5），且根据氨基糖苷类药物不同而有所变化：妥布霉素和奈替米星为65%，阿米卡星为76%，庆大霉素为81%。这些联合的协同作用增强了头孢替安的活性：在测试的36株菌株中，分别与妥布霉素、奈替米星、庆大霉素或阿米卡星联合时，83%、78%和76%的菌株对头孢替安敏感（MIC小于或等于4微克/毫升）。