Department of Geography and Division of Epidemiology, The Ohio State University, Columbus, OH, United States.
Department of Biostatistics, University of Kentucky, Lexington, KY, United States.
Drug Alcohol Depend. 2021 Nov 1;228:108977. doi: 10.1016/j.drugalcdep.2021.108977. Epub 2021 Aug 28.
Although national syndromic surveillance data reported declines in emergency department (ED) visits after the declaration of the national stay-at-home order for COVID-19, little is known whether these declines were observed for suspected opioid overdose.
This interrupted time series study used syndromic surveillance data from four states participating in the HEALing Communities Study: Kentucky, Massachusetts, New York, and Ohio. All ED encounters for suspected opioid overdose (n = 48,301) occurring during the first 31 weeks of 2020 were included. We examined the impact of the national public health emergency for COVID-19 (declared on March 14, 2020) on trends in ED encounters for suspected opioid overdose.
Three of four states (Massachusetts, New York and Ohio) experienced a statistically significant immediate decline in the rate of ED encounters for suspected opioid overdose (per 100,000) after the nationwide public health emergency declaration (MA: -0.99; 95 % CI: -1.75, -0.24; NY: -0.10; 95 % CI, -0.20, 0.0; OH: -0.33, 95 % CI: -0.58, -0.07). After this date, Ohio and Kentucky experienced a sustained rate of increase for a 13-week period. New York experienced a decrease in the rate of ED encounters for a 10-week period, after which the rate began to increase. In Massachusetts after a significant immediate decline in the rate of ED encounters, there was no significant difference in the rate of change for a 6-week period, followed by an immediate increase in the ED rate to higher than pre-COVID levels.
The heterogeneity in the trends in ED encounters between the four sites show that the national stay-at-home order had a differential impact on opioid overdose ED presentation in each state.
尽管国家综合征监测数据报告在宣布 COVID-19 全国居家令后,急诊科 (ED) 就诊量有所下降,但对于疑似阿片类药物过量的下降情况却知之甚少。
这项中断时间序列研究使用了参与 HEALing 社区研究的四个州的综合征监测数据:肯塔基州、马萨诸塞州、纽约州和俄亥俄州。所有在 2020 年的前 31 周内发生的疑似阿片类药物过量的 ED 就诊(n=48301)均包括在内。我们研究了 COVID-19 国家公共卫生紧急情况(2020 年 3 月 14 日宣布)对疑似阿片类药物过量的 ED 就诊趋势的影响。
在全国公共卫生紧急情况宣布后,四个州中的三个州(马萨诸塞州、纽约州和俄亥俄州)的疑似阿片类药物过量的 ED 就诊率(每 10 万人)立即出现了统计学上的显著下降(MA:-0.99;95%CI:-1.75,-0.24;NY:-0.10;95%CI,-0.20,0.0;OH:-0.33,95%CI:-0.58,-0.07)。在此日期之后,俄亥俄州和肯塔基州经历了持续的 13 周的增长率。纽约州经历了 10 周的 ED 就诊率下降,之后该比率开始上升。在马萨诸塞州,ED 就诊率立即显著下降后,在 6 周的时间内,变化率没有显著差异,随后 ED 就诊率立即增加到高于 COVID-19 前的水平。
四个地点的 ED 就诊趋势的异质性表明,全国居家令对每个州的阿片类药物过量 ED 表现产生了不同的影响。