Department of Dentistry, Yuyao People's Hospital of Zhejiang Province, Yuyao, China.
Department of Dentistology, First Hospital of Ninghai County, Ninghai, China.
Clin Invest Med. 2021 Oct 3;44(3). doi: 10.25011/cim.v44i3.36477.
Purpose: To investigate the therapeutic effects of minocycline combined with tinidazole in the treatment of chronic periodontitis (CP). Methods: Seventy-three CP patients treated May 2018–December 2019 at Yuyao People’s Hospital (Yuyao, China) were enrolled in this study: 34 were treated with minocycline alone (control group; CG) and 39 were treated with a combination of minocycline and tinidazole (observation group; OG). Both groups were treated continuously for four weeks and plaque index (PLI), bleeding index (BI), periodontal pocket depth (PD), periodontal attachment level (PAL) and alveolar bone height were compared before and after treatment. Pain was evaluated using the visual analogue scale (VAS). Levels of TNF-α and IL-6 before and after treatment were determined using an enzyme-linked immunosorbent assay. Adverse reactions were compared. Results: In each group, PLI, BI, PD, PAL and alveolar bone height were lower after treatment (P<0.05), and those in OG were lower than those in CG (P<0.05). TNF-α and IL-6 levels in both groups were lower after treatment (P<0.05), and the levels in serum of the OG were lower than those of the CG (P<0.05). After treatment, the VAS in OG was lower than that of CG (P<0.05). There was no significant difference in adverse reactions between groups (P>0.05). Conclusion: Minocycline combined with tinidazole was more effective in treating CP than minocycline alone. This drug combination improved the periodontal indexes and inflammatory reaction of CP and relieved their pain. No significant difference in adverse reactions was seen.
探讨米诺环素联合替硝唑治疗慢性牙周炎（CP）的疗效。方法：选取 2018 年 5 月至 2019 年 12 月在余姚市人民医院（余姚，中国）治疗的 73 例 CP 患者进行本研究：34 例单独接受米诺环素治疗（对照组；CG），39 例接受米诺环素联合替硝唑治疗（观察组；OG）。两组均连续治疗 4 周，比较治疗前后菌斑指数（PLI）、出血指数（BI）、牙周袋深度（PD）、牙周附着水平（PAL）和牙槽骨高度。采用视觉模拟评分（VAS）评估疼痛。采用酶联免疫吸附试验（ELISA）测定治疗前后 TNF-α和 IL-6 水平。比较不良反应。结果：两组治疗后 PLI、BI、PD、PAL 和牙槽骨高度均降低（P<0.05），OG 低于 CG（P<0.05）。两组治疗后 TNF-α和 IL-6 水平均降低（P<0.05），OG 低于 CG（P<0.05）。OG 治疗后的 VAS 低于 CG（P<0.05）。两组不良反应发生率无统计学差异（P>0.05）。结论：米诺环素联合替硝唑治疗 CP 优于单独使用米诺环素。该药物联合治疗改善了 CP 的牙周指数和炎症反应，缓解了疼痛。不良反应无显著差异。
