Chen Qiang, Yan Wen, Geng Nan
Department of Periodontics, Suzhou Stomatological Hospital, Suzhou, Jiangsu 215000, China.
Center of Stomatology, The Second Affiliated Hospital of Soochow University, No 1055 Sanxiang Road, Soochow 215004, China.
Evid Based Complement Alternat Med. 2022 Jul 4;2022:7604741. doi: 10.1155/2022/7604741. eCollection 2022.
To explore the efficacy of Minocycline hydrochloride combined with multiple antibiotic pastes in the treatment of chronic periodontitis with concomitant pulp lesions in elderly patients, as well as to analyze the changes in the levels of inflammatory markers.
100 patients suffering from chronic periodontitis with concomitant pulp lesions treated in our hospital from July 2018 to January 2020 were selected as the study subjects, and were randomly assigned to either an experimental group ( = 50) or a control group ( = 50). Patients in the experimental group were treated with Minocycline hydrochloride combined with multiple antibiotic pastes, while those in the control group were treated with Minocycline hydrochloride alone. The treatment efficacy in the two groups was then assessed using such factors as periodontal probing depth, dental plaque index, gingival index, periodontal attachment level, and the presence or absence of adverse effects. We also measured and compared the levels of inflammatory markers such as CRP, TNF-, IL-1, IL-5, IL-6, and others in both groups, before treatment, as well as after a week of treatment.
There was a statistically significant difference in the treatment efficacy between the two groups ( < 0.05), with a higher treatment efficacy seen in the experimental group as compared to the control group. When compared to the control group, the experimental group had lower depths of periodontal probing, lower dental plaque indices, lower gingival indices, lower periodontal attachment levels, as well a significantly lower incidence of adverse reactions ( < 0.05). Before treatment, the levels of inflammatory markers such as CRP, TNF-, IL-1, IL-5, and IL-6 were elevated in both groups. After a week of treatment, there were reductions in the levels of inflammatory markers in both groups, but a more significant reduction was seen in the experimental than in the control group ( < 0.05).
Minocycline hydrochloride combined with various antibiotic pastes is more effective in the treatment of chronic periodontitis with concomitant pulp lesions in elderly patients than monotherapy with Minocycline hydrochloride alone.
探讨盐酸米诺环素联合多种抗生素糊剂治疗老年慢性牙周炎伴牙髓病变的疗效，并分析炎症标志物水平的变化。
选取2018年7月至2020年1月在我院治疗的100例慢性牙周炎伴牙髓病变患者作为研究对象，随机分为实验组（n = 50）和对照组（n = 50）。实验组患者采用盐酸米诺环素联合多种抗生素糊剂治疗，对照组患者仅采用盐酸米诺环素治疗。然后，使用牙周探诊深度、牙菌斑指数、牙龈指数、牙周附着水平以及不良反应的发生情况等因素评估两组的治疗效果。我们还测量并比较了两组在治疗前以及治疗一周后的炎症标志物如CRP、TNF-α、IL-1、IL-5、IL-6等的水平。
两组治疗效果存在统计学差异（P < 0.05），实验组的治疗效果高于对照组。与对照组相比，实验组的牙周探诊深度更低、牙菌斑指数更低、牙龈指数更低、牙周附着水平更低，不良反应发生率也显著更低（P < 0.05）。治疗前，两组的炎症标志物如CRP、TNF-α、IL-1、IL-5和IL-6水平均升高。治疗一周后，两组的炎症标志物水平均有所降低，但实验组的降低幅度比对照组更显著（P < 0.05）。
盐酸米诺环素联合多种抗生素糊剂治疗老年慢性牙周炎伴牙髓病变比单独使用盐酸米诺环素单一疗法更有效。
