Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain; Universidad Nacional Agraria la Molina, Facultad de Industrias Alimentarias, Innovative Technology, Food and Health Research Group, La Molina, Lima, Perú.
Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain.
Food Res Int. 2021 Nov;149:110655. doi: 10.1016/j.foodres.2021.110655. Epub 2021 Aug 20.
Most randomized clinical trials of polyphenols focus on individual foods. Nevertheless, due to their presence in many foods and in order to reflect a real situation, clinical trials based on polyphenol-rich diets are particularly important. This systematic review explores the characteristics of the polyphenol-rich diets used in intervention studies. The bibliography search for English-language scientific papers was performed in the Elsevier Scopus Database and PUBMED in March 2020, and focused on intervention studies with whole polyphenol-rich diets, establishing several exclusion criteria. In studies fulfilling the requirements, information on the design of the polyphenol-rich diet and associated polyphenol intake was extracted and compared. A total of 5 studies were selected. Among them, substantial differences were found in the design of the polyphenol-rich diets, regarding specific instructions and concerning the foods provided. Similarly, although a median daily polyphenol intake of 2,564 mg/day (17,945 mg/week) was obtained from the studies, which corresponds to a nutritional dose, intake values varied widely both for total polyphenols (the difference between studies reached threefold), and for individual polyphenol intake (for hydroxycinnamic acids, a tenfold difference was found between percentile 25 and percentile 75 values). These differences made the comparison of results difficult and may affected the observed health effects. Thus, despite the relevance of studying polyphenol-rich diets as a whole, this systematic review found substantial differences between the studies performed, making direct comparisons difficult.
大多数多酚的随机临床试验都集中在单一食物上。然而，由于多酚存在于许多食物中，为了反映真实情况，基于富含多酚的饮食的临床试验尤为重要。本系统综述探讨了干预研究中使用的富含多酚饮食的特点。2020 年 3 月，我们在爱思唯尔 Scopus 数据库和 PUBMED 中对英文科学论文进行了文献检索，并重点关注了全多酚丰富饮食的干预研究，制定了几项排除标准。在符合要求的研究中，提取并比较了富含多酚饮食设计及相关多酚摄入量的信息。共选择了 5 项研究。其中，富含多酚饮食的设计存在很大差异，具体表现在具体说明和提供的食物方面。同样，尽管研究中获得的每日多酚摄入量中位数为 2564mg/d（17945mg/周），相当于营养剂量，但总多酚的摄入量差异很大（研究之间的差异达到三倍），而且个体多酚的摄入量也有很大差异（对于羟基肉桂酸，25 百分位和 75 百分位之间的摄入量差异达到 10 倍）。这些差异使得结果的比较变得困难，并且可能影响到观察到的健康效果。因此，尽管研究富含多酚的饮食作为一个整体具有重要意义，但本系统综述发现，所进行的研究之间存在很大差异，使得直接比较变得困难。
