冠状病毒病（COVID-19）患者的临床特征：日本COVID-19特别工作组的初步基线报告，该工作组是一个调查COVID-19宿主遗传学的全国性联盟。
Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19.
作者信息
Tanaka Hiromu, Lee Ho, Morita Atsuho, Namkoong Ho, Chubachi Shotaro, Kabata Hiroki, Kamata Hirofumi, Ishii Makoto, Hasegawa Naoki, Harada Norihiro, Ueda Tetsuya, Ueda Soichiro, Ishiguro Takashi, Arimura Ken, Saito Fukuki, Yoshiyama Takashi, Nakano Yasushi, Mutoh Yoshikazu, Suzuki Yusuke, Murakami Koji, Okada Yukinori, Koike Ryuji, Kitagawa Yuko, Tokunaga Katsushi, Kimura Akinori, Imoto Seiya, Miyano Satoru, Ogawa Seishi, Kanai Takanori, Fukunaga Koichi
机构信息
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
出版信息
Int J Infect Dis. 2021 Dec;113:74-81. doi: 10.1016/j.ijid.2021.09.070. Epub 2021 Sep 30.
BACKGROUND AND DESIGN
The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. The Japan COVID-19 Task Force is conducting host genome analysis of hospitalized patients with COVID-19 from more than 70 institutions nationwide in Japan. This report describes the clinical characteristics of patients enrolled to date.
RESULTS
The median (interquartile range) age of the 1674 patients included in the analysis was 59 (45-71) years, and more than half of the patients (66.2%) were male. Less than half of the patients (41.2%) had severe disease. The case fatality rate was 3.2%.
CONCLUSIONS
Since this is a hospital-based study, the number of severe cases was relatively high, but the case fatality rate was relatively low, when compared to that of other countries. In the future, we will continue to enroll patients and conduct genome analyses of patients with COVID-19.
背景与设计
冠状病毒病（COVID-19）大流行正在全球范围内产生毁灭性影响。不同人群的宿主基因组差异可能会影响COVID-19的严重程度。日本COVID-19特别工作组正在对来自日本全国70多家机构的COVID-19住院患者进行宿主基因组分析。本报告描述了截至目前入组患者的临床特征。
结果
纳入分析的1674例患者的年龄中位数（四分位间距）为59（45 - 71）岁，超过半数患者（66.2%）为男性。不到半数患者（41.2%）患有重症疾病。病死率为3.2%。
结论
由于这是一项基于医院的研究，与其他国家相比，重症病例数相对较高，但病死率相对较低。未来，我们将继续纳入患者并对COVID-19患者进行基因组分析。
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