2021年1月至3月期间，法国的新冠病毒变异株与较低的逆转录聚合酶链反应（RT-PCR）扩增循环数相关。
SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France.
作者信息
Roquebert Benedicte, Haim-Boukobza Stéphanie, Trombert-Paolantoni Sabine, Lecorche Emmanuel, Verdurme Laura, Foulongne Vincent, Burrel Sonia, Alizon Samuel, Sofonea Mircea T
机构信息
Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
Laboratoire de Virologie, CHU de Montpellier - 80 av Augustin Fliche, Montpellier 34295, France.
出版信息
Int J Infect Dis. 2021 Dec;113:12-14. doi: 10.1016/j.ijid.2021.09.076. Epub 2021 Oct 1.
SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变种引发了对2019冠状病毒病（COVID-19）疫情所致死亡率的担忧。我们分析了2021年1月26日至3月13日期间进行的变种特异性逆转录聚合酶链反应（RT-PCR）检测的88375个循环扩增（Ct）值。我们估计，在3月12日，近85%的感染是由阿尔法变种引起的，其相对于野生型毒株的传播优势在38%至44%之间。我们还发现，阿尔法变种和贝塔/伽马变种检测呈阳性的样本显示出明显更低的循环阈值（Ct）值。
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