Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS / 3B's - PT Government Associate Laboratory, Braga / Guimarães, Portugal.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS / 3B's - PT Government Associate Laboratory, Braga / Guimarães, Portugal; Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.
Complement Ther Clin Pract. 2021 Nov;45:101486. doi: 10.1016/j.ctcp.2021.101486. Epub 2021 Sep 29.
Pain is a common condition among people with hemophilia (PWH), negatively impacting quality of life. However, effective treatment remains a challenge. This two-arm, parallel randomized controlled pilot trial aimed to examine the three-month effects of hypnosis intervention on clinical and psychosocial variables, and on the inflammatory profile of PWH.
The study was conducted between January and October 2018, in a Reference Center for Congenital Coagulopathies. Adult (age ≥18) patients were randomized to experimental group (EG) or control group (CG). The EG received four weekly hypnosis sessions plus treatment-as-usual, and the CG maintained treatment-as-usual only. Outcomes were evaluated at one week and three months post-intervention and included pain, joint status, health-related quality of life (HRQoL), emotional state and inflammatory profile (leukocytes, C-reactive protein, cytokines). The randomization sequence was computer-generated, and allocation was concealed until enrolment. The outcome assessor was blind to allocation, but blinding of the participants was not possible due to the differences in procedure.
Twenty patients were randomized to EG (n = 10; 8 analyzed) or CG (n = 10; 10 analyzed). Two-way mixed ANOVA showed significant time × group interactions on pain interference with normal work and with relations with other people, and on perception of health status. The EG significantly improved in pain interference with normal work and perception of health status. There was no report of harm.
Hypnosis may be a promising intervention to manage hemophilia-related pain and promote HRQoL, with benefits lasting up to three months.
疼痛是血友病患者（PWH）的常见病症，会对生活质量产生负面影响。然而，有效的治疗仍然是一个挑战。本项双臂、平行随机对照初步试验旨在探讨催眠干预对 PWH 的临床和社会心理变量以及炎症特征的三个月影响。
该研究于 2018 年 1 月至 10 月在先天性凝血障碍参考中心进行，纳入成年（年龄≥18 岁）患者，随机分为实验组（EG）或对照组（CG）。EG 接受每周 4 次催眠治疗，外加常规治疗，CG 仅接受常规治疗。在干预后一周和三个月评估结局，包括疼痛、关节状况、健康相关生活质量（HRQoL）、情绪状态和炎症特征（白细胞、C 反应蛋白、细胞因子）。随机序列由计算机生成，分配在入组前隐藏。结局评估者对分组情况不知情，但由于程序差异，无法对患者进行盲法。
20 例患者被随机分配至 EG（n=10；8 例分析）或 CG（n=10；10 例分析）。双因素混合方差分析显示，疼痛对正常工作和人际关系的干扰以及对健康状况的感知在时间和分组上存在显著交互作用。EG 在疼痛对正常工作的干扰和对健康状况的感知方面均有显著改善。未报告不良事件。
催眠可能是一种有前途的干预手段，可用于管理血友病相关疼痛和提高 HRQoL，其益处可持续长达三个月。
