Department of Gastroenterology and Hepatology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawaku, Yokohama, 236-0004, Japan.
Cardiovascular and Diabetes, Product Marketing Department, Kowa Company, Ltd., 3-4-10 Nihonbashi Honcho, Tokyo, 103-0023, Japan.
J Gastroenterol. 2021 Nov;56(11):1022-1032. doi: 10.1007/s00535-021-01828-6. Epub 2021 Oct 3.
Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated fatty liver disease (MAFLD) have important associations with cardiovascular disease (CVD). The main objective of this study was to compare the frequency of incidence rate of CVD in the NAFLD or MAFLD patients utilizing a large claims database.
Using the JMDC database from April 2013 to March 2019, we retrospectively analyzed data for 1,542,688 and 2,452,949 people to estimate the relationship between CVD and NAFLD, MAFLD, respectively.
The incidence rates of CVD were 0.97 (95% CI 0.94-1.01) and 2.82 (95% CI 2.64-3.01) per 1000 person-years in the non-NAFLD and NAFLD groups, respectively, and 1.01 (95% CI 0.98-1.03) and 2.69 (95% CI 2.55-2.83) per 1000 person-years in the non-MAFLD and MAFLD groups, respectively. The overall prevalence of hypertriglyceridemia and diabetes mellitus (DM) was 13.1, and 4.2%, respectively, in the non-NAFLD group and 63.6, and 20.2%, respectively, in the NAFLD group. The overall prevalenceof hypertriglyceridemia and DM was 13.6 and 4.3%, respectively, in the non-MAFLD group and 64.1, and 20.6%, respectively, in the MAFLD group. HRs for CVD increased with hypertriglyceridemia and DM.
Results indicated that incident rate of CVD increased with NAFLD/MAFLD; the complication rate of DM and hypertriglyceridemia among NAFLD/MAFLD patients is high and may affect the development of CVD.
非酒精性脂肪性肝病（NAFLD）和代谢相关脂肪性肝病（MAFLD）与心血管疾病（CVD）有重要关联。本研究的主要目的是利用大型理赔数据库比较 NAFLD 或 MAFLD 患者 CVD 的发病率。
使用 JMDC 数据库，我们回顾性分析了 2013 年 4 月至 2019 年 3 月的 1542688 人和 2452949 人数据，以分别估计 CVD 与 NAFLD 和 MAFLD 的关系。
非 NAFLD 组和 NAFLD 组 CVD 的发病率分别为 0.97（95%CI 0.94-1.01）和 2.82（95%CI 0.94-1.01）/1000 人年，非 MAFLD 组和 MAFLD 组分别为 1.01（95%CI 0.98-1.03）和 2.69（95%CI 2.55-2.83）/1000 人年。非 NAFLD 组高甘油三酯血症和糖尿病（DM）的总体患病率分别为 13.1%和 4.2%，NAFLD 组分别为 63.6%和 20.2%。非 MAFLD 组高甘油三酯血症和 DM 的总体患病率分别为 13.6%和 4.3%，MAFLD 组分别为 64.1%和 20.6%。CVD 的 HR 随着高甘油三酯血症和 DM 而增加。
结果表明，CVD 的发病率随着 NAFLD/MAFLD 的增加而增加；NAFLD/MAFLD 患者的 DM 和高甘油三酯血症的并发症发生率较高，可能会影响 CVD 的发展。
