Zhang Yue, Xu Jialu, Fei Ziying, Dai Huaxing, Fan Qin, Yang Qianyu, Chen Yitong, Wang Beilei, Wang Chao
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
Adv Mater. 2021 Dec;33(48):e2106768. doi: 10.1002/adma.202106768. Epub 2021 Oct 15.
Cancer vaccine platform has attracted great interest in the field of cancer immunotherapy. Here, 3D printed scaffolds loaded with immunoregulators are developed for enhanced cancer immunotherapy. The rapid manufacturing and precise molding based on 3D printing can realize the mass manufacturing of cancer vaccines and personalized design. Meanwhile, compared to the traditional hydrogel, the 3D-scaffold with porous structure endows its similar functions compared with real lymphoid organs by recruitment of a great number of immune cells, leading to the formation of "artificial tertiary lymphoid structures," where there is a promising site to enhance both humoral and cellular immune responses. Efficient anticancer immunity is induced when combined with immune checkpoint blockade to inhibit the tumor growth. Personalized antitumor scaffold vaccines are further demonstrated for filling of tumor site after surgery to prevent cancer metastasis. Taken together, these results promise the 3D printing scaffold vaccine as the potential strategy for cancer vaccine therapy in the future.
癌症疫苗平台在癌症免疫治疗领域引起了极大的关注。在此，开发了负载免疫调节剂的3D打印支架用于增强癌症免疫治疗。基于3D打印的快速制造和精确成型能够实现癌症疫苗的大规模生产以及个性化设计。同时，与传统水凝胶相比，具有多孔结构的3D支架通过募集大量免疫细胞赋予其与真实淋巴器官相似的功能，从而导致“人工三级淋巴结构”的形成，这是增强体液免疫和细胞免疫反应的理想位点。与免疫检查点阻断联合使用时可诱导有效的抗癌免疫，从而抑制肿瘤生长。进一步证明了个性化抗肿瘤支架疫苗可用于术后填充肿瘤部位以预防癌症转移。综上所述，这些结果表明3D打印支架疫苗有望成为未来癌症疫苗治疗的潜在策略。
