Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
J Cosmet Dermatol. 2022 Jul;21(7):2971-2976. doi: 10.1111/jocd.14490. Epub 2021 Oct 3.
Serum leptin, an adipocytokine of interleukin-6 family, has been linked to vitiligo-associated metabolic derangements. Additionally, it has been proposed as an inflammatory mediator with possible influence on vitiligo pathogenesis. This study aimed at assessing serum leptin in vitiligo patients compared to controls and whether different vitiligo characteristics have an influence on serum leptin levels.
In this hospital-based, cross-sectional case-control study, 70 vitiligo (35 segmental vitiligo (SV) and 35 Non-segmental vitiligo (NSV)) and 70 age- and sex-matched controls were assessed for different anthropometric measurements including waist circumference (WC), index of central obesity (ICO), and body mass index (BMI) as well as serum leptin levels.
Central obesity as per ICO showed no significant difference between patients and controls. Additionally, patients of SV and NSV collectively showed significant higher incidence of +ve serum leptin than their controls (41.4% vs. 22.9%%, P: 0.019). Mere presence of vitiligo and ICO >0.5 were highlighted as independent predictors of +ve serum leptin (P: 0.009 and <0.001, respectively).
Inability to determine a cause/effect relationship based on a cross-sectional study. Larger scale studies are needed to affirm our findings.
Mere presence of vitiligo being an independent predictor for high serum leptin could be either a contributor to pathogenesis of vitiligo or a sequel to accumulating evidence of metabolic nature of vitiligo. This is likely to influence the investigative panel and treatment protocol for vitiligo patients.
血清瘦素是白细胞介素-6 家族的一种脂肪细胞因子，与白癜风相关的代谢紊乱有关。此外，它被认为是一种具有潜在影响白癜风发病机制的炎症介质。本研究旨在评估白癜风患者与对照组的血清瘦素水平，并探讨不同的白癜风特征对血清瘦素水平的影响。
在这项基于医院的横断面病例对照研究中，评估了 70 例白癜风患者（35 例节段性白癜风（SV）和 35 例非节段性白癜风（NSV））和 70 名年龄和性别匹配的对照组的不同人体测量指标，包括腰围（WC）、中心肥胖指数（ICO）和体重指数（BMI）以及血清瘦素水平。
ICO 显示患者和对照组之间的中心肥胖无显著差异。此外，SV 和 NSV 患者的阳性血清瘦素发生率显著高于对照组（41.4%比 22.9%，P：0.019）。单纯存在白癜风和 ICO>0.5 是阳性血清瘦素的独立预测因素（P：分别为 0.009 和<0.001）。
由于这是一项横断面研究，因此无法确定因果关系。需要更大规模的研究来证实我们的发现。
单纯存在白癜风是高血清瘦素的独立预测因素，这可能是白癜风发病机制的一个因素，也可能是白癜风代谢性质的累积证据的结果。这可能会影响白癜风患者的调查小组和治疗方案。
