Białczyk Aleksandra, Kamińska Barbara, Czajkowski Rafał
Department of Dermatology and Venereology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatol Alergol. 2025 Apr 15;42(2):134-142. doi: 10.5114/ada.2025.149438. eCollection 2025 Apr.
Vitiligo is a chronic autoimmune disorder linked to systemic inflammation, oxidative stress, and metabolic dysregulation, including metabolic syndrome (MetS). This review examines the shared mechanisms underlying vitiligo and MetS, highlighting oxidative stress, pro-inflammatory cytokines, and lipid dysregulation as central contributors. A systematic analysis of 23 studies found association between vitiligo and MetS, though variations exist based on the disease type, severity, and duration. Emerging therapies, such as statins and thiazolidinediones demonstrate potential for managing vitiligo and its metabolic risks by targeting oxidative and inflammatory pathways. While animal and studies show promise, clinical outcomes are inconsistent, with safety concerns limiting systemic treatments.
白癜风是一种慢性自身免疫性疾病，与全身炎症、氧化应激和代谢失调（包括代谢综合征）有关。本综述探讨了白癜风和代谢综合征的共同潜在机制，强调氧化应激、促炎细胞因子和脂质失调是主要促成因素。对23项研究的系统分析发现白癜风与代谢综合征之间存在关联，不过根据疾病类型、严重程度和病程存在差异。他汀类药物和噻唑烷二酮类等新兴疗法通过靶向氧化和炎症途径，显示出治疗白癜风及其代谢风险的潜力。虽然动物研究和[此处原文可能有误，推测是“人体研究”]显示出前景，但临床结果并不一致，安全问题限制了全身治疗。
