Karadurmus Leyla, Gumustas Mehmet, Bakirhan Nurgul K, Ozkan Sibel A
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Department of Analytical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Turkey.
Crit Rev Anal Chem. 2023;53(3):498-519. doi: 10.1080/10408347.2021.1967108. Epub 2021 Oct 3.
Chirality is an academically exciting and interesting topic, as most active ingredients have chirality. Chiral enantiomers with the same molecular shape show different effects from each other in terms of pharmacological, pharmacokinetic, and toxicology. There are many examples of these differences that have caused dramatic, even fatal damage. For these reasons, it is of great importance to developing an effective method to achieve chiral identification and separation, and chiral separation methods are becoming increasingly important in both the pharmaceutical industry and clinical studies. Electrochemical techniques, which can provide many advantages over other classical methods, have attracted great interest in chiral recognition in recent years. In this review, extensive and critical research of the trends in chiral recognition in recent studies is explained. Especially the role of cyclodextrins derivatives in chiral analysis has been investigated and the studies related to this are explained and given in the tables. In addition, some remarks and future perspectives in the field of chiral recognition are also discussed in the concluding part.
手性是一个在学术上令人兴奋且有趣的话题，因为大多数活性成分都具有手性。具有相同分子形状的手性对映体在药理、药代动力学和毒理学方面表现出彼此不同的效应。有许多这些差异导致巨大甚至致命损害的例子。基于这些原因，开发一种有效的手性识别和分离方法非常重要，并且手性分离方法在制药行业和临床研究中都变得越来越重要。与其他经典方法相比能提供许多优势的电化学技术，近年来在手性识别方面引起了极大的兴趣。在这篇综述中，解释了近期研究中对手性识别趋势的广泛且批判性的研究。特别研究了环糊精衍生物在手性分析中的作用，并在表格中解释并给出了与此相关的研究。此外，在结论部分还讨论了手性识别领域的一些评论和未来展望。
