Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Expert Opin Ther Targets. 2021 Aug;25(8):615-619. doi: 10.1080/14728222.2021.1982896. Epub 2021 Oct 4.
The tumor microenvironment, which includes the vasculature, is critical to tumor progression. The vasculature architecture can also influence therapeutic response by modulating the delivery of chemotherapy. Only a few studies have looked at vascular biology in medulloblastoma tumors, although existing studies suggest that neurodevelopmental pathways and chromatin-remodelers may contribute to angiogenic growth in these tumors. Clinical studies with bevacizumab in combination with radiation or chemotherapy have not been very successful. Chromatin remodelers can be pharmacologically targeted, and should be evaluated in pre-clinical models for their anti-angiogenic activity.
肿瘤微环境包括脉管系统,对肿瘤的进展至关重要。脉管系统的结构也可以通过调节化疗药物的输送来影响治疗反应。尽管已有研究表明神经发育途径和染色质重塑剂可能有助于这些肿瘤的血管生成生长,但只有少数研究关注了髓母细胞瘤中的血管生物学。贝伐珠单抗联合放疗或化疗的临床研究并不十分成功。染色质重塑剂可以进行药理学靶向,并且应该在临床前模型中评估其抗血管生成活性。